Mild Encephalopathy with Reversible Splenic Lesions in an Infant with COVID-19

There have been few reports of mild encephalopathy with reversible splenic lesions (MERS) associated with COVID-19 in infants. Here, we present a case of MERS in a 23-month-old infant with COVID-19 in Japan during the Omicron variant epidemic. The increase in COVID-19 acute encephalopathy in infants, including those with MERS, should be considered in the future due to the prevalence of the Omicron variant strain. Meanwhile, whether the cause is COVID-19, acute encephalopathy with a lesion localized in the splenium of the corpus callosum can be treated with temporary anticonvulsant therapy, as is generally the case with MERS.