一种提高来氟米特溶解度的实用方法

IF 0.3 Q4 CHEMISTRY, MULTIDISCIPLINARY Oriental Journal Of Chemistry Pub Date : 2023-10-30 DOI:10.13005/ojc/390537
Yash Bhandari, Sunayana Rathore, Vaishali Raghuwanshi, Shehnaz Sheikh, Yashmita Sharma, Ishan Dubey
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引用次数: 0

摘要

来氟米特是一种抗风湿病药物。由于其水溶性低,在胃肠道中的吸收较低。据报道来氟米特的溶解度约为25.27微克/毫升。来氟米特属于BCS II类,具有低溶解度和高渗透性。本研究采用凝胶包埋技术提高来氟米特的溶解度。该工艺以羟丙基甲基纤维素和乙基纤维素为原料,加入不同的有机溶剂,如乙醇、氯仿、二氯甲烷等,将其转化为凝胶。样品的分析用紫外分光光度计在260nm。结果表明,凝胶包埋技术可使来氟米特药物的溶解度增加,分别为HPMC+氯仿、HPMC+乙醇+二氯甲烷、HPMC+乙醇+水、HPMC+乙基纤维素+二氯甲烷+水的5.23倍、3.80倍、3.05倍和2.64倍。
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A Practical Approach for Solubility Enhancement of Leflunomide
Leflunomide is an anti-rheumatic medication. As it has low water solubility, it shows low absorption in gastrointestinal tract. The reported solubility of Leflunomide is approx 25.27 mcg/ml. Leflunomide comes under BCS Class II in which it has low solubility and high permeability. In this study, gel entrapment technique is used to enhance the solubility of leflunomide. In this technique Hydroxy Propyl Methyl Cellulose and Ethyl Cellulose are used which are converted to gel with the addition of different organic solvent such as Ethanol, Chloroform, Di chloro Methane etc. The analyses of the samples are done by UV Spectrophotometer at 260nm. Results shows an increment in solubility of Leflunomide drug by gel entrapment technique and are found to be 5.23, 3.80, 3.05 and 2.64 times using HPMC+Chloroform, HPMC+Ethanol+ Dichloro methane, HPMC+Ethanol+Water, HPMC+Ethyl Cellulose+ Dichloro methane+ Water respectively.
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来源期刊
Oriental Journal Of Chemistry
Oriental Journal Of Chemistry CHEMISTRY, MULTIDISCIPLINARY-
自引率
20.00%
发文量
172
期刊介绍: Oriental Journal of Chemistry was started in 1985 with the aim to promote chemistry research. The journal consists of articles which are rigorously peer-reviewed. The journal was indexed in Emerging Science citation index in 2016. The Editorial board member consists of eminent international scientist in all fields of Chemistry. Details of each member and their contact information is mentioned in website. The journal has thorough ethics policies and uses plagiarism detection software(ithenticate) to screen each submission. The journal has recently partnered with publons as a part of making our reviews more transparent. The journal has recently incorporated PlumX for article level matrix. The journal is promoting research on all social and academic platforms mentioned in PlumX guidelines. The journal uses google maps to improve on the geographical distribution of Editorial board members as well as authors.
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