打破链条:抗击尼帕病毒感染的抗病毒战略取得进展

Fredmoore L. Orosco
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引用次数: 0

摘要

尼帕病毒(NiV)是一种高致病性人畜共患病毒,已在人类和动物中引起多次暴发,死亡率很高,因此需要采取“同一个健康”方法。没有针对NiV感染的特异性治疗方法或疫苗,因此开发针对该病毒的有效抗病毒药物成为关键的研究重点。近年来,人们在寻找和开发针对NiV发病各阶段的抗病毒药物方面做出了重大努力。本文综述了国内外抗病毒药物的研究现状。本文还重点介绍了几种化合物的研究成果,包括重新利用药物、核苷类似物、植物化学物质和多靶点抑制剂。开发有效的抗病毒药物仍然是一个重大挑战;然而,最近在了解NiV发病机制和确定抗病毒药物潜在靶点方面的进展为未来提供了希望。需要进一步的研究来确定和优化对NiV和其他相关病毒具有广谱活性的抗病毒药物。
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Breaking the chains: Advancements in antiviral strategies to combat Nipah virus infections
Nipah virus (NiV) is a highly pathogenic zoonotic virus that has caused several outbreaks with high fatality rates in humans and animals, thus, requiring a “One Health” approach. No specific treatment or vaccine is available for NiV infection, making the development of effective antiviral agents against this virus a critical research priority. In recent years, significant efforts have been made to identify and develop antiviral agents targeting the various stages of NiV pathogenesis. This review comprehensively discusses current research on antiviral agents against NiV. The promising results obtained with several compounds, including repurposed drugs, nucleoside analogs, phytochemicals, and multi-target inhibitors, are also highlighted. Developing effective antiviral agents against NiV remains a major challenge; however, recent advances in understanding the mechanisms of NiV pathogenesis and identifying potential targets for antiviral agents have provided hope for the future. Further research is required to identify and optimize antiviral agents with broad-spectrum activity against NiV and other related viruses.
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来源期刊
International Journal of One Health
International Journal of One Health Veterinary-Veterinary (all)
CiteScore
2.10
自引率
0.00%
发文量
13
审稿时长
15 weeks
期刊介绍: International Journal of One Health publishes high quality and novelty papers focusing on One Health. Review articles are highly appreciated. All articles published by International Journal of One Health are made freely and permanently accessible online. All articles to International Journal of One Health are posted online immediately as they are ready for publication.
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