亚的斯亚贝巴,埃塞俄比亚血液和组织库服务中自愿献血者小血型系统抗原及其表型的评估

IF 1.5 Q3 HEALTH CARE SCIENCES & SERVICES Ethiopian Journal of Health Sciences Pub Date : 2023-09-21 DOI:10.4314/ejhs.v33i5.11
Getu Jenbere, Fekadu Urgessa, Melatwork Tibebu
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引用次数: 0

摘要

背景:红细胞抗原在结构和功能上具有多样性;有些是蛋白质,有些是碳水化合物。国际输血学会目前承认43种血型系统包含349种红细胞抗原。它还承认9种血型系统(ABO、Rhesus、Kell、Duffy、Kidd、MNS、P、Lewis和Lutheran)具有临床意义并与溶血性输血反应以及胎儿和新生儿溶血性疾病相关。本研究的目的是评估亚的斯亚贝巴埃塞俄比亚血液和组织库服务的自愿献血者中次要血型抗原的分布及其表型。方法:于2022年1月至3月在埃塞俄比亚亚的斯亚贝巴的EBTBS对260名志愿献血者进行横断面研究,以确定次要血型抗原及其表型。测试使用Galileo Neo Immucor,这是一种全自动免疫血液学分析仪。 结果:共筛查献血者260人,其中男性153人(59%)。少数血型系统抗原频率分别为:Fy(a)、Fy(b)、Jk(a)、Jk(b)、k、S、S分别为33.5%、43.5%、97.7%、40.4%、100%、45%、90%。在表型分布方面,最常见的表型为:Duffy Fy (a-b+) 36.9%, MNS S-s+ 55%和Kidd Jk (a+b-) 59.6%. 结论:本研究突出了亚的斯亚贝巴EBTBS志愿献血者Fy(a)、Fy(b)、Jk(a)、Jk(b)、k、S和S血型抗原的频率及其表型。对于输血患者同种异体免疫病例的管理,了解这些小血型抗原是相关的。
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Assessment of Minor Blood Group System Antigens and Their Phenotype among Voluntary Blood Donors in Ethiopian Blood and Tissue Bank Service, Addis Ababa, Ethiopia
Background: Red blood cell antigens are numerous in structural and functional diversity; some are proteins while others are carbohydrates. The international society of blood transfusion currently recognized 43 blood group systems containing 349 red cell antigens. It also acknowledged 9 blood group systems (ABO, Rhesus, Kell, Duffy, Kidd, MNS, P, Lewis, and Lutheran) that are clinically significant and associated with hemolytic transfusion reactions as well as hemolytic disease of fetuses and newborns. The objective of this study was to assess the distribution of minor blood group antigens and their phenotype among voluntary blood donors in Ethiopian blood and tissue bank service in Addis Ababa. Method: A cross-sectional study was conducted from January to March 2022 among 260 volunteer blood donors to determine minor blood group antigens and their phenotype at EBTBS, Addis Ababa, Ethiopia. Tests were performed using Galileo Neo Immucor, which is fully automated Immunohematology analyzer. Result: A total of 260 blood donors were screened of which 153 (59%) were males. The antigen frequencies of minor blood group systems were: Fy(a), Fy(b), Jk(a), Jk(b), k, S, s were 33.5%, 43.5%, 97.7%, 40.4%, 100%, 45%, 90%, respectively. Regarding phenotype distribution, the most common phenotypes were: Duffy Fy (a-b+) 36.9%, MNS S-s+ 55% and Kidd Jk (a+b-) 59.6%. Conclusion: This study highlights the frequencies of Fy(a), Fy(b), Jk(a), Jk(b), k, S and s blood group antigens and their phenotypes in volunteer blood donors at EBTBS, Addis Ababa. For the management of alloimmunization cases in transfused patients, knowledge of these minor blood group antigens is relevant.
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来源期刊
Ethiopian Journal of Health Sciences
Ethiopian Journal of Health Sciences HEALTH CARE SCIENCES & SERVICES-
CiteScore
2.10
自引率
8.30%
发文量
137
审稿时长
12 weeks
期刊介绍: Ethiopian Journal of Health Sciences is a general health science journal addressing clinical medicine, public health and biomedical sciences. Rarely, it covers veterinary medicine
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