稳定期COPD患者单核细胞-高密度脂蛋白比值与病程、肺功能及肺动脉高压的关系

IF 0.3 Q3 MEDICINE, GENERAL & INTERNAL Cukurova Medical Journal Pub Date : 2023-09-30 DOI:10.17826/cumj.1315487
Efraim GÜZEL, Burak METE, Sedat KULECİ, Yasemin SAYGİDEGER, Oya BAYDAR TOPRAK
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 Materials and Methodsː The study was conducted by acquiring retrospective data from previously recorded questionnaires and hospital databases for 239 individuals over the age of 40 with a diagnosis of COPD who admitted to the outpatient clinic. Patients whose data were missing were not included in the analysis. Two groups of patients were created: those with high MHO levels and those without. Analysis was done on the correlation between high MHO and COPD and pulmonary function tests. The presence of PH in COPD patients was analyzed in the second stage. 
 Resultsː The median age of the patients was 62.22 ± 9.37 year and 88.7% of them were male. With the exception of smoking, there was no statistically significant link between high MHR and COPD in the analyses, however there was a negative connection between post-bronchodilation (post-BD) FEV1/FVC and MHR. Additionally, the statistically significant negative association was found between the absolute monocyte value and RV/TLC. However, older age (OR=0.949, 95% CI (0.915, 0.984)), having more than three comorbidities (OR=2.174, 95% CI (1.045, 4.521)), and having a body mass index (BMI) below 25 have all been linked to an increased risk of PH in COPD patients.
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引用次数: 0

摘要

目的:炎症是慢性阻塞性肺疾病(COPD)病理生理的一个主要因素,与炎症相关的分子包括单核细胞和高密度脂蛋白-胆固醇(HDL-C)。该研究的主要目的是观察COPD患者肺功能、肺动脉高压(PH)和单核细胞/高密度脂蛋白比值(MHR)之间的关系。材料和方法:本研究通过从先前记录的问卷调查和医院数据库中获取239名40岁以上门诊就诊的慢性阻塞性肺病患者的回顾性数据进行。数据缺失的患者不包括在分析中。研究人员创建了两组患者:高MHO水平的患者和低MHO水平的患者。分析高MHO与COPD及肺功能的相关性。在第二阶段分析COPD患者PH的存在。& # x0D;结果患者中位年龄为62.22±9.37岁,男性占88.7%。除吸烟外,在分析中,高MHR和COPD之间没有统计学意义上的联系,但支气管扩张后(bd后)FEV1/FVC与MHR之间存在负相关。此外,单核细胞绝对值与RV/TLC呈显著负相关。然而,年龄较大(OR=0.949, 95% CI(0.915, 0.984))、有三种以上合并症(OR=2.174, 95% CI(1.045, 4.521))以及体重指数(BMI)低于25均与COPD患者PH风险增加有关。 结论:虽然MHR与COPD之间的联系尚未最终确定,但它与肺功能有关。该研究还得出结论,PH值可能因老年、多种合并症和低体重而显著升高。这些问题必须在更大的、多中心的患者群体中进行调查和验证。
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Relationship between monocyte-HDL ratio and disease process and pulmonary functions and pulmonary hypertension in stable COPD patients
Purpose: Inflammation is a major factor in the pathophysiology of chronic obstructive pulmonary disease (COPD), and molecules implicated in inflammation include monocytes and high-density lipoprotein-cholesterol (HDL-C). The primary goal of the study was to look at the relationship between pulmonary function and pulmonary hypertension (PH) in COPD and the monocyte to HDL ratio (MHR). Materials and Methodsː The study was conducted by acquiring retrospective data from previously recorded questionnaires and hospital databases for 239 individuals over the age of 40 with a diagnosis of COPD who admitted to the outpatient clinic. Patients whose data were missing were not included in the analysis. Two groups of patients were created: those with high MHO levels and those without. Analysis was done on the correlation between high MHO and COPD and pulmonary function tests. The presence of PH in COPD patients was analyzed in the second stage. Resultsː The median age of the patients was 62.22 ± 9.37 year and 88.7% of them were male. With the exception of smoking, there was no statistically significant link between high MHR and COPD in the analyses, however there was a negative connection between post-bronchodilation (post-BD) FEV1/FVC and MHR. Additionally, the statistically significant negative association was found between the absolute monocyte value and RV/TLC. However, older age (OR=0.949, 95% CI (0.915, 0.984)), having more than three comorbidities (OR=2.174, 95% CI (1.045, 4.521)), and having a body mass index (BMI) below 25 have all been linked to an increased risk of PH in COPD patients. Conclusionː Although the link between MHR and COPD was not conclusively established, it was linked to pulmonary functions. The study that was presented also came to the conclusion that PH may be significantly increased by advanced age, numerous comorbidities, and low body weight. These problems must be investigated and validated in larger, multicenter patient populations.
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来源期刊
Cukurova Medical Journal
Cukurova Medical Journal MEDICINE, GENERAL & INTERNAL-
自引率
0.00%
发文量
159
审稿时长
12 weeks
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