首发精神分裂症:患者及其一级亲属的精神病学和认知研究

Ola Othman Mahmoud Abdellatif, Amr Adel Haiba, Adel Abd El-Kareem Badawy, Hossam Eldin Fathallah Elsawy
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摘要

背景:严重和持续性精神状况成人终生精神分裂症患病率为0.4%至1%。本研究的目的是比较首发精神分裂症患者的认知功能与多发性精神分裂症患者的认知功能,并探讨首发精神分裂症患者的认知功能以及治疗对患者一级亲属的影响。 方法:本研究纳入200例横断面病例对照研究,男女均有,年龄18 ~ 50岁。受试者分为五组:第一组(n=50):精神分裂症初期发作。第二组(n=50):精神分裂症患者首次发作的亲属。第三组(n=50):多次发作的精神分裂症。健康志愿者组成第四组(n=50)。V组(n=36): 1组患者治疗1年后随访。 结果:总智商、注意力、执行功能、记忆功能和社会认知在两组间存在显著差异。一级亲属组与对照组在注意力、执行功能和记忆功能上存在显著差异。用韦氏记忆量表(WMS)测量完成的威斯康辛卡片分类测验(WCST)类别和保存错误数、造径测验(TMT) A、B、Mayer-Salovey-Caruso情绪智力感知和体验领域(MESCIT)、精神控制、逻辑记忆、数字总数、联想学习和视觉再现。除知觉分支和经验区域(社会认知)外,总体智商、WCST、Benton视觉保留测试(BVRT)和MESCIT均无统计学意义的变化。结论:首发患者在一般智力、注意力、执行功能、记忆功能、社会认知等方面表现优于多次首发患者。
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First Episode Schizophrenia: Psychiatric and Cognitive Study for the Patients and Their First-degree Relatives
Background: severe and persistent mental condition Adults have a lifetime prevalence of schizophrenia that ranges from 0.4 to 1%. The purpose of this study was to compare the cognitive function of first-episode schizophrenic patients to that of multiple schizophrenic patients, as well as to examine cognitive function in patients with first-episode schizophrenia and the impact of treatment on first-degree relatives of the patient. Methods: The 200 participants in this cross-sectional case-control study were of both sexes and ranged in age from 18 to 50. There were five groups created for the subjects: Group I (n=50): Schizophrenia in its initial episode. Group II (n=50): Relatives of schizophrenia patients experiencing their first episode. Group III (n=50): Schizophrenia with multiple episodes. Healthy volunteers make up Group IV (n=50). Group V (n=36): Group I was followed up with one year following therapy. Results: Total IQ, attention, executive function, memory function, and social cognition were significantly different between patients and controls. First-degree relatives and the control group showed substantial differences in attention, executive function, and memory function. The Wisconsin Card Sorting Test (WCST) categories that were completed and the number of preservation errors, as well as the Trail Making Test (TMT) A and B, Mayer-Salovey-Caruso Perception and experiencing areas of emotional intelligence (MESCIT), mental control, logical memory, total number of digits, association learning, and visual reproduction are all measured by the Wechsler Memory Scale (WMS). Other than the perception branch and experiential region (social cognition), there was no statistically significant change in the overall IQ, WCST, Benton Visual Retention Test (BVRT), or MESCIT. Conclusions: In terms of general intelligence, attention, executive function, memory function, and social cognition, first episode patients outperformed many episode patients.
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