解锁药用植物治疗阿尔茨海默病的潜力:临床前到临床试验的见解

Kushagra Nagori, Kartik T. Nakhate, Krishna Yadav, None Ajazuddin, Madhulika Pradhan
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摘要

阿尔茨海默病(AD)是一种进行性、多因素、持续的神经退行性疾病,以记忆丧失、人格改变和认知障碍为特征。近年来,它变得更加普遍。因此,了解阿尔茨海默病的病理生理学和制定有效的治疗策略是至关重要的。此外,疾病的进展不受迄今为止发现的药物方法的影响。此外,在过去十年中,超过200种潜在的候选药物在临床试验中失败,这表明该疾病及其潜在原因的复杂性和艰难性。因此,研究以药用植物为基础的天然产物在寻找新的神经保护治疗候选AD是至关重要的。事实上,一些科学研究已经证明了许多药用植物及其主要植物化学物质在治疗AD方面的功效。本文就阿尔茨海默病的病理生理机制、天然药物抗阿尔茨海默病的必要性以及近年来神经保护药用植物及其生物活性化合物在阿尔茨海默病有效治疗中的作用的临床前研究进行了综述。此外,该综述还介绍了有前途的抗ad配方/植物源性药物的临床试验数据。揭示最近的发现和突出与阿尔茨海默病新疗法开发相关的临床试验数据将促进该领域的进一步研究,并为开发更有效和安全的治疗这种使人衰弱的疾病的方法铺平道路。
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Unlocking the Therapeutic Potential of Medicinal Plants for Alzheimer’s Disease: Preclinical to Clinical Trial Insights
Alzheimer’s disease (AD) is a progressive, multifactorial, and unremitting neurodegenerative disease characterized by memory loss, personality changes, and cognitive impairment. It has become more prevalent in recent years. Therefore, understanding the pathophysiology of AD and developing efficient therapeutic strategies are essential. Moreover, the progression of the disease is unaffected by the pharmaceutical approaches discovered to date. Additionally, the failure of over 200 potential drug candidates in clinical trials over the past decade suggests the complexity and difficulty of both the disease and its underlying causes. Therefore, research focused on medicinal plant-based natural products in the search for novel neuroprotective therapeutic candidates for AD is essential. Indeed, several scientific investigations have demonstrated the efficacy of many medicinal plants and their principal phytochemicals in the treatment of AD. This review article covered the pathophysiological mechanisms of AD, the necessity for natural products as anti-AD treatments, and the most recent preclinical studies revealing the function of neuroprotective medicinal plants and their bioactive compounds in the effective management of AD. In addition, the review also presents clinical trial data of promising anti-AD formulations/agents of plant origin. Revealing recent findings and highlighting the clinical trial data related to the development of new treatments for AD would promote further research in this field and pave the way for the development of more effective and safe treatments for this debilitating disease.
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