Florencia Antunovic, Felipe Tolosa, Catherine Klein, René Ocaranza
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引用次数: 0
摘要
背景:聚己内酯(PCL)是一种生物相容性好、易于制造和机械强度高的合成聚合物,在骨组织工程中得到高度认可。其应用范围广泛,包括口腔颌面部缺损组织的再生。再生牙槽骨、牙周韧带和牙骨质等牙周缺损组织的研究引起了人们的重视。本系统综述的目的是获得基于pcl的支架在牙槽骨再生过程中的贡献的最新分析。方法:本综述遵循PRISMA(系统评价和荟萃分析的首选报告项目)指南进行系统评价。对PubMed、EBSCO、Scielo和Web of Science数据库进行计算机检索,将文献检索限制为2002年1月至2023年3月期间发表的英语或西班牙语研究。数据库检索返回248项研究,这些研究是根据标题、作者姓名和出版日期筛选的。结果:我们回顾了17项研究的数据并将其制成表格。所有的研究都将PCL与其他生物材料(如海藻酸盐、羟基磷灰石、生物活性玻璃、聚乳酸-羟基乙酸)、生长因子(BMP-2、rhCEMP1)和/或间充质间质细胞(脂肪来源、骨髓、牙周韧带或牙龈间充质间质细胞)结合使用。PCL支架与生物活性物质结合后,具有较高的细胞活力和成骨诱导潜能。此外,其降解率受特定物质的添加或暴露的影响,如:多巴胺、氧化铈、PLGA和过氧化氢。结论:PCL是一种有效的牙槽骨再生生物材料。它可能是新一代生物材料的一部分,具有更好的再生潜力。
Polycaprolactone-based scaffolds for guided tissue regeneration in periodontal therapy: A systematic review.
Background: Polycaprolactone (PCL) is a highly recognized synthetic polymer for its biocompatibility, ease of fabrication and mechanical strength in bone tissue engineering. Its applications have extended broadly, including regeneration of oral and maxillofacial lost tissues. Its usefulness has brought attention of researchers to regenerate periodontal lost tissues, including alveolar bone, periodontal ligament and cementum. The aim of this systematic review was to obtain an updated analysis of the contribution of PCL-based scaffolds in the alveolar bone regeneration process.
Methods: This review adheres to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines for systematic reviews. A computerized search of the PubMed, EBSCO, Scielo and Web of Science databases was performed, restricting literature search to published studies in English or Spanish between January 2002 and March 2023. Database search returned 248 studies which were screened based on title, author names and publication dates.
Results: Data from 17 studies were reviewed and tabulated. All studies combined PCL with other biomaterials (such as Alginate, hydroxyapatite, bioactive glass, poly (lactic-co-glycolic acid)), growth factors (BMP-2, rhCEMP1), and/or mesenchymal stromal cells (adipose-derived, bone marrow, periodontal ligament or gingiva mesenchymal stromal cells). PCL scaffolds showed higher cell viability and osteoinductive potential when combined with bioactive agents. Complementary, its degradation rates were affected by the addition or exposure to specific substances, such as: Dopamine, Cerium Oxide, PLGA and hydrogen peroxide.
Conclusions: PCL is an effective biomaterial for alveolar bone regeneration in periodontally affected teeth. It could be part of a new generation of biomaterials with improved regenerative potential.
期刊介绍:
The Journal of Applied Biomaterials & Functional Materials (JABFM) is an open access, peer-reviewed, international journal considering the publication of original contributions, reviews and editorials dealing with clinical and laboratory investigations in the fast growing field of biomaterial sciences and functional materials.
The areas covered by the journal will include:
• Biomaterials / Materials for biomedical applications
• Functional materials
• Hybrid and composite materials
• Soft materials
• Hydrogels
• Nanomaterials
• Gene delivery
• Nonodevices
• Metamaterials
• Active coatings
• Surface functionalization
• Tissue engineering
• Cell delivery/cell encapsulation systems
• 3D printing materials
• Material characterization
• Biomechanics