肾移植受者亚临床非hla AMR检测和监测dd-cfDNA

Q4 Medicine Transplantation Reports Pub Date : 2022-03-01 DOI:10.1016/j.tpr.2022.100092

Erik L. Lum , Sabrina Lee , Jonathan Zuckerman , Suphamai Bunnapradist

{"title":"肾移植受者亚临床非hla AMR检测和监测dd-cfDNA","authors":"Erik L. Lum , Sabrina Lee , Jonathan Zuckerman , Suphamai Bunnapradist","doi":"10.1016/j.tpr.2022.100092","DOIUrl":null,"url":null,"abstract":"<div><p>Elevations in dd-cfDNA at the time of kidney allograft dysfunction are associated with an increased risk of rejection. The utility of such measurements in a stable allograft is unknown. Herein we present a case utilizing routine surveillance dd-cfDNA to detect subclinical active BANFF rejection with persistent elevations and biopsy evidence of ongoing injury despite treatments. Due to treatment failure she developed chronic allograft nephropathy within six months of transplantation. Surveillance and post treatment monitoring of dd-cfDNA may be useful early detection and monitoring of rejection in kidney transplant recipients and as a marker in future studies.</p></div>","PeriodicalId":37786,"journal":{"name":"Transplantation Reports","volume":"7 1","pages":"Article 100092"},"PeriodicalIF":0.0000,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2451959622000014/pdfft?md5=1127432b2f9dfc84560d097790aabfaf&pid=1-s2.0-S2451959622000014-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Subclinical non-HLA AMR detection and monitoring with surveillance dd-cfDNA in a kidney transplant recipient\",\"authors\":\"Erik L. Lum , Sabrina Lee , Jonathan Zuckerman , Suphamai Bunnapradist\",\"doi\":\"10.1016/j.tpr.2022.100092\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Elevations in dd-cfDNA at the time of kidney allograft dysfunction are associated with an increased risk of rejection. The utility of such measurements in a stable allograft is unknown. Herein we present a case utilizing routine surveillance dd-cfDNA to detect subclinical active BANFF rejection with persistent elevations and biopsy evidence of ongoing injury despite treatments. Due to treatment failure she developed chronic allograft nephropathy within six months of transplantation. Surveillance and post treatment monitoring of dd-cfDNA may be useful early detection and monitoring of rejection in kidney transplant recipients and as a marker in future studies.</p></div>\",\"PeriodicalId\":37786,\"journal\":{\"name\":\"Transplantation Reports\",\"volume\":\"7 1\",\"pages\":\"Article 100092\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2451959622000014/pdfft?md5=1127432b2f9dfc84560d097790aabfaf&pid=1-s2.0-S2451959622000014-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Transplantation Reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2451959622000014\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Transplantation Reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2451959622000014","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

摘要

同种异体肾移植功能障碍时dd-cfDNA升高与排斥反应风险增加有关。这种测量在稳定的同种异体移植物中的效用尚不清楚。在此，我们报告了一个病例，利用常规监测dd-cfDNA检测亚临床活动性BANFF排斥反应，持续升高，活检证据表明，尽管治疗，仍存在持续损伤。由于治疗失败，她在移植后6个月内患上了慢性同种异体肾病。监测和治疗后监测dd-cfDNA可能有助于早期发现和监测肾移植受者的排斥反应，并在未来的研究中作为一个标记。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

Subclinical non-HLA AMR detection and monitoring with surveillance dd-cfDNA in a kidney transplant recipient

Elevations in dd-cfDNA at the time of kidney allograft dysfunction are associated with an increased risk of rejection. The utility of such measurements in a stable allograft is unknown. Herein we present a case utilizing routine surveillance dd-cfDNA to detect subclinical active BANFF rejection with persistent elevations and biopsy evidence of ongoing injury despite treatments. Due to treatment failure she developed chronic allograft nephropathy within six months of transplantation. Surveillance and post treatment monitoring of dd-cfDNA may be useful early detection and monitoring of rejection in kidney transplant recipients and as a marker in future studies.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Transplantation Reports Medicine-Transplantation

CiteScore

0.60

自引率

0.00%

发文量

审稿时长

101 days

期刊介绍： To provide to national and regional audiences experiences unique to them or confirming of broader concepts originating in large controlled trials. All aspects of organ, tissue and cell transplantation clinically and experimentally. Transplantation Reports will provide in-depth representation of emerging preclinical, impactful and clinical experiences. -Original basic or clinical science articles that represent initial limited experiences as preliminary reports. -Clinical trials of therapies previously well documented in large trials but now tested in limited, special, ethnic or clinically unique patient populations. -Case studies that confirm prior reports but have occurred in patients displaying unique clinical characteristics such as ethnicities or rarely associated co-morbidities. Transplantation Reports offers these benefits: -Fast and fair peer review -Rapid, article-based publication -Unrivalled visibility and exposure for your research -Immediate, free and permanent access to your paper on Science Direct -Immediately citable using the article DOI