I Jemna, D Cioflec, N Ion, O Hudiţeanu, I Lego, I Simon
{"title":"分枝杆菌耐药现状及其对抗结核治疗的启示。","authors":"I Jemna, D Cioflec, N Ion, O Hudiţeanu, I Lego, I Simon","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The data in the present paper consider, for a longer period, the secondary and the initial drug resistance in pulmonary and extrapulmonary tuberculosis. The paper studies mainly the period of the last 9 years (1979-1987) in comparison with a previous period of 6 years (1973-1978). The 2,194 antibiograms performed for 7 common tuberculostatics show an increase, in the last years, of the general resistance of the germs from 24.3% to 36%. The increase of the resistance is noticed to all the tuberculostatics, but mainly to Rifampicin, from 14.8% to 49.3% and to streptomycin, from 22.7% to 44.8%. An important increase is found, at present, mainly in the drug resistance of germs in the extrapulmonary specimens (lymph nodes 28.5% and CSF 40%) to streptomycin and INH.</p>","PeriodicalId":76439,"journal":{"name":"Revista de igiena, bacteriologie, virusologie, parazitologie, epidemiologie, pneumoftiziologie. Pneumoftiziologia","volume":"38 2","pages":"143-8"},"PeriodicalIF":0.0000,"publicationDate":"1989-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[The current situation of mycobacterial chemoresistance and its implications for antitubercular treatment].\",\"authors\":\"I Jemna, D Cioflec, N Ion, O Hudiţeanu, I Lego, I Simon\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The data in the present paper consider, for a longer period, the secondary and the initial drug resistance in pulmonary and extrapulmonary tuberculosis. The paper studies mainly the period of the last 9 years (1979-1987) in comparison with a previous period of 6 years (1973-1978). The 2,194 antibiograms performed for 7 common tuberculostatics show an increase, in the last years, of the general resistance of the germs from 24.3% to 36%. The increase of the resistance is noticed to all the tuberculostatics, but mainly to Rifampicin, from 14.8% to 49.3% and to streptomycin, from 22.7% to 44.8%. An important increase is found, at present, mainly in the drug resistance of germs in the extrapulmonary specimens (lymph nodes 28.5% and CSF 40%) to streptomycin and INH.</p>\",\"PeriodicalId\":76439,\"journal\":{\"name\":\"Revista de igiena, bacteriologie, virusologie, parazitologie, epidemiologie, pneumoftiziologie. Pneumoftiziologia\",\"volume\":\"38 2\",\"pages\":\"143-8\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1989-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Revista de igiena, bacteriologie, virusologie, parazitologie, epidemiologie, pneumoftiziologie. Pneumoftiziologia\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revista de igiena, bacteriologie, virusologie, parazitologie, epidemiologie, pneumoftiziologie. Pneumoftiziologia","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
[The current situation of mycobacterial chemoresistance and its implications for antitubercular treatment].
The data in the present paper consider, for a longer period, the secondary and the initial drug resistance in pulmonary and extrapulmonary tuberculosis. The paper studies mainly the period of the last 9 years (1979-1987) in comparison with a previous period of 6 years (1973-1978). The 2,194 antibiograms performed for 7 common tuberculostatics show an increase, in the last years, of the general resistance of the germs from 24.3% to 36%. The increase of the resistance is noticed to all the tuberculostatics, but mainly to Rifampicin, from 14.8% to 49.3% and to streptomycin, from 22.7% to 44.8%. An important increase is found, at present, mainly in the drug resistance of germs in the extrapulmonary specimens (lymph nodes 28.5% and CSF 40%) to streptomycin and INH.