{"title":"钙调素在心脏肌膜钙通量调节中的作用。","authors":"E Carafoli","doi":"10.1007/978-1-4757-1287-2_7","DOIUrl":null,"url":null,"abstract":"<p><p>Three systems mediate the fluxes of calcium across heart sarcolemma: the slow calcium channel (influx), the ATP-dependent calcium pump (efflux), and the Na+/Ca2+ exchanger (efflux, but possibly also influx). Calmodulin regulates the pumping ATPase by direct interaction and also by activating a protein kinase. The Na+/Ca2+ exchanger is modulated by calmodulin via a phosphorylation-dephosphorylation cycle. Both the kinase and the phosphatase are membrane-bound and calmodulin-sensitive. The kinase has higher Ca2+ affinity than the phosphatase.</p>","PeriodicalId":77831,"journal":{"name":"Advances in myocardiology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"7","resultStr":"{\"title\":\"Calmodulin in the regulation of calcium fluxes in cardiac sarcolemma.\",\"authors\":\"E Carafoli\",\"doi\":\"10.1007/978-1-4757-1287-2_7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Three systems mediate the fluxes of calcium across heart sarcolemma: the slow calcium channel (influx), the ATP-dependent calcium pump (efflux), and the Na+/Ca2+ exchanger (efflux, but possibly also influx). Calmodulin regulates the pumping ATPase by direct interaction and also by activating a protein kinase. The Na+/Ca2+ exchanger is modulated by calmodulin via a phosphorylation-dephosphorylation cycle. Both the kinase and the phosphatase are membrane-bound and calmodulin-sensitive. The kinase has higher Ca2+ affinity than the phosphatase.</p>\",\"PeriodicalId\":77831,\"journal\":{\"name\":\"Advances in myocardiology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1985-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"7\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advances in myocardiology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1007/978-1-4757-1287-2_7\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in myocardiology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/978-1-4757-1287-2_7","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Calmodulin in the regulation of calcium fluxes in cardiac sarcolemma.
Three systems mediate the fluxes of calcium across heart sarcolemma: the slow calcium channel (influx), the ATP-dependent calcium pump (efflux), and the Na+/Ca2+ exchanger (efflux, but possibly also influx). Calmodulin regulates the pumping ATPase by direct interaction and also by activating a protein kinase. The Na+/Ca2+ exchanger is modulated by calmodulin via a phosphorylation-dephosphorylation cycle. Both the kinase and the phosphatase are membrane-bound and calmodulin-sensitive. The kinase has higher Ca2+ affinity than the phosphatase.
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