类固醇磺化酶抑制剂和硫酸C19类固醇治疗蛋白质毒性相关疾病:专利焦点

IF 1.8 Q3 PHARMACOLOGY & PHARMACY Pharmaceutical patent analyst Pub Date : 2023-09-01 Epub Date: 2023-11-20 DOI:10.4155/ppa-2023-0010
Rami A Al-Horani
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引用次数: 0

摘要

衰老和蛋白质毒性是密切相关的。抑制蛋白质毒性被认为可以延长寿命。本发明描述了一种限制蛋白质毒性和延长寿命的新策略。秀丽隐杆线虫类固醇硫酸酯酶sul2功能的丧失,增加了硫酸类固醇激素的数量,延长了寿命,改善了蛋白质聚集性疾病。本发明提供了一组分子,用于预防由蛋白质聚集疾病引起的与衰老相关的蛋白质毒性和/或增加真核生物的寿命。这些分子要么是类固醇硫酸酯酶抑制剂,要么是硫酸C19类固醇,两者都能产生硫-2突变体的表型。一个典型的例子是STX-64。这些说法的潜在应用已经在帕金森病、亨廷顿病和阿尔茨海默病的动物模型中得到证实。
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Steroid sulfatase inhibitors and sulfated C19 steroids for proteotoxicity-related diseases: a patent spotlight.

Aging and proteotoxicity go hand in hand. Inhibiting proteotoxicity has been proposed to extend lifespan. This invention describes a new strategy to limit proteotoxicity and to extend the lifespan. Loss of function of sul-2, the Caenorhabditis elegans steroid sulfatase, elevates the pool of sulfated steroid hormones, increases longevity and ameliorates protein aggregation diseases. The present invention provides a group of molecules for use in the prevention of aging-associated proteotoxicity caused by protein aggregation diseases and/or to increase the lifespan of a eukaryotic organism. These molecules are either steroid sulfatase inhibitors or sulfated C19 steroids, both of which reproduce the phenotype of sul-2 mutants. One particular representative example is STX-64. Potential applications of the claims have been demonstrated in animal models of Parkinson's disease, Huntington's disease and Alzheimer's disease.

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Pharmaceutical patent analyst
Pharmaceutical patent analyst PHARMACOLOGY & PHARMACY-
CiteScore
1.80
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0.00%
发文量
22
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