血管内NK/ t细胞淋巴瘤1例报告及文献复习。

IF 1.7 Q3 PATHOLOGY Journal of Pathology and Translational Medicine Pub Date : 2023-11-01 Epub Date: 2023-11-14 DOI:10.4132/jptm.2023.10.30
Ji Min Na, Wookjae Jung, Minhye Kim, Yun-Hong Cheon, Jong Sil Lee, Dae Hyun Song, Jung Wook Yang
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引用次数: 0

摘要

血管内淋巴瘤的特点是肿瘤细胞仅在血管内分布。血管内自然杀伤/ t细胞淋巴瘤(IVNKTL)极为罕见,侵袭性强,通常为eb病毒阳性,主要影响皮肤和中枢神经系统。在这里,我们报告一例确诊为IVNKTL的67岁女性,表现为持续间歇性发热和全身皮疹。胸部红斑病变的切口活检显示,小血管腔内聚集了中至大的非典型淋巴样细胞,免疫组织化学和ebv编码RNA原位杂交显示CD3、颗粒酶B和CD56阳性。诊断后血清中也检测到EBV DNA。通过对26例IVNKTL病例的回顾,我们认为基于EBV DNA检测的主动活检可能有助于IVNKTL的早期诊断。
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Intravascular NK/T-cell lymphoma: a case report and literature review.

Intravascular lymphoma is characterized by an exclusively intravascular distribution of tumor cells. Intravascular natural killer/T-cell lymphoma (IVNKTL) is extremely rare, highly aggressive, commonly Epstein-Barr virus (EBV)-positive, and predominantly affects the skin and central nervous system. Here we report a case of IVNKTL diagnosed in a 67-year-old female, presenting with persistent intermittent fever and skin rashes throughout the body. Incisional biopsy of an erythematous lesion on the chest exhibited aggregation of medium to large-sized atypical lymphoid cells confined to the lumen of small vessels that were positive for CD3, granzyme B, and CD56 on immunohistochemistry and EBV-encoded RNA in situ hybridization. EBV DNA was also detected in serum after diagnosis. With a review of 26 cases of IVNKTL to date, we suggest that active biopsy based on EBV DNA detection may facilitate early diagnosis of IVNKTL.

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来源期刊
CiteScore
5.00
自引率
4.20%
发文量
45
审稿时长
14 weeks
期刊介绍: The Journal of Pathology and Translational Medicine is an open venue for the rapid publication of major achievements in various fields of pathology, cytopathology, and biomedical and translational research. The Journal aims to share new insights into the molecular and cellular mechanisms of human diseases and to report major advances in both experimental and clinical medicine, with a particular emphasis on translational research. The investigations of human cells and tissues using high-dimensional biology techniques such as genomics and proteomics will be given a high priority. Articles on stem cell biology are also welcome. The categories of manuscript include original articles, review and perspective articles, case studies, brief case reports, and letters to the editor.
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