骨关节炎的药物前景。

Drug design and delivery Pub Date : 1989-06-01
H A Bird
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引用次数: 0

摘要

骨关节炎的传统治疗方法是使用止痛药、非甾体抗炎药和关节内类固醇。新型镇痛药的开发和类固醇的重新配制以增强局部活动都值得关注。这种疾病的缓慢进程使得新药的评估变得困难。我们需要更敏感的评估或人类加速发展模型。在可能具有基本作用的药物中,透明质酸和所谓的“软骨保护”剂最近引起了人们的兴趣。他们的发展突出了协调足够的剂量范围的药代动力学研究与研究者治疗疾病的热情的困难,这种疾病可能会有一个波动的过程,自发的改善。
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Drug prospects in osteoarthritis.

The traditional treatment for osteoarthritis is with analgesics, NSAIDs and intra-articular steroids. The development of novel analgesics and the reformulation of steroids to enhance local activity both deserve attention. The disease's slow course makes evaluation of new drugs difficult. More sensitive assessments or perhaps human models of accelerated progression are required. Amongst the drugs that might have fundamental action, hyaluronic acid and the so-called 'chondroprotective' agents have attracted recent interest. Their development highlights the difficulty of reconciling adequate dose-ranging pharmacokinetic studies with investigators' enthusiasm for treating a disease that may be subject to a fluctuant course with spontaneous improvement.

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