神经肽和单胺作为淋巴细胞活化拮抗剂的治疗潜力。

Drug design and delivery Pub Date : 1989-06-01
K Nordlind, V Mutt, E Sundström
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引用次数: 0

摘要

神经肽和单胺存在于启动免疫反应的组织中,如皮肤、肠道和呼吸道。在这些组织中,它们可能影响炎症性疾病中的淋巴细胞活化。刺激和抑制作用都有描述。这种抑制作用可能具有病理生理学和药理学意义。体外和体内研究表明,各种神经肽和单胺可能抑制T淋巴细胞增殖、淋巴细胞增殖和抗体合成、淋巴细胞迁移和细胞毒性等反应。
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The therapeutic potential of neuropeptides and monoamines as antagonists of lymphocyte activation.

Neuropeptides and monoamines are found in tissues where immune reactions are initiated such as the skin, gut and respiratory tract. In these tissues they might influence lymphocyte activation in inflammatory diseases. Both stimulatory and inhibitory effects have been described. The inhibitory effects may prove to be of pathophysiological and pharmacological importance. Studies both in vitro and in vivo showing that various neuropeptides and monoamines may inhibit reactions such as T lymphocyte proliferation, Blymphocyte proliferation and antibody synthesis, lymphocyte migration and cytotoxicity, are reviewed.

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