离子通道及其在化学抗性中的作用。

4区 生物学 Q4 Biochemistry, Genetics and Molecular Biology Current topics in membranes Pub Date : 2023-01-01 Epub Date: 2023-11-10 DOI:10.1016/bs.ctm.2023.09.008
Davide Antonio Delisi, Maedeh Vakili Saatloo
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引用次数: 0

摘要

离子通道在细胞信号传导、体内平衡以及电信号和化学信号的产生中起着至关重要的作用。离子通道的异常表达和失调与癌症的发展和对化疗等常规癌症治疗的耐药性有关。人们提出了几种分子机制来解释这一现象。包括逃避细胞凋亡,减少癌细胞中的药物积累,解毒和激活其他逃逸途径,如自噬。这些机制中的每一种都会导致药物治疗效果的降低,给癌症治疗带来更多的困难。本文综述了离子通道与化疗耐药之间的联系。进一步阐述了它们的分子机制和在临床管理中作为治疗靶点的潜力。
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Ion channels and their role in chemo-resistance.

Ion channels play a crucial role in cellular signaling, homeostasis, and generation of electrical and chemical signals. Aberrant expression and dysregulation of ion channels have been associated with cancer development and resistance to conventional cancer treatment such as chemotherapy. Several molecular mechanisms have been proposed to explain this phenomenon. Including evasion of apoptosis, decreased drug accumulation in cancer cells, detoxifying and activation of alternative escape pathways such as autophagy. Each of these mechanisms leads to a reduction of the therapeutic efficacy of administered drugs, causing more difficulty in cancer treatment. This review highlights the linkages between ion channels and resistance to chemotherapy. Furthermore, it elaborates their molecular mechanisms and the potential of being therapeutic targets in clinical management.

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来源期刊
Current topics in membranes
Current topics in membranes 生物-生化与分子生物学
CiteScore
3.50
自引率
0.00%
发文量
10
审稿时长
>12 weeks
期刊介绍: Current Topics in Membranes provides a systematic, comprehensive, and rigorous approach to specific topics relevant to the study of cellular membranes. Each volume is a guest edited compendium of membrane biology.
期刊最新文献
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