微rna和代谢物在肺癌诊断中的作用:一项荟萃分析。

IF 0.7 Q3 Medicine ASIAN CARDIOVASCULAR & THORACIC ANNALS Pub Date : 2024-01-01 Epub Date: 2023-11-27 DOI:10.1177/02184923231215538
Mona Mlika, Mohamed Majdi Zorgati, Mehdi Abdennadher, Imen Bouassida, Faouzi Mezni, Ali Mrabet
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引用次数: 0

摘要

背景:肺癌的诊断是基于组织或液体的显微镜检查。近十年来,许多生物标志物已被指出具有潜在的诊断作用。这些生物标志物可以在血液、胸腔积液或痰中进行评估,它们可以避免活检或其他危险的程序。作者旨在评估以微rna和代谢物为重点的生物标志物的诊断性能。方法:本荟萃分析在PRISMA指南下进行,为期9年(2013-2022年)。使用Meta-Disc软件5.4(免费版)。采用Q检验和I2统计分析各研究间的异质性。在异质性显著的情况下进行meta回归。采用漏斗图检验和Egger检验(免费版JASP)评估发表偏倚。结果:根据我们的纳入标准,我们纳入了来自79篇文章的165项研究。合并后的SEN、SPE和dOR分别为0.76、0.79和13.927。AUC估计为0.859,表明诊断准确性较好。合并SEN和SPE的异质性具有统计学意义。荟萃回归分析的重点是所使用的技术、样本、生物标志物数量、生物标志物亚型、肿瘤分期和种族,结果显示生物标志物数量(p = 0.009)和肿瘤分期(p = 0.0241)是潜在的异质性来源。结论:即使这项荟萃分析强调了生物标志物的潜在诊断效用,也应该进行更多的前瞻性研究,特别是评估生物标志物在早期肺癌中的诊断潜力。
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The diagnostic performance of micro-RNA and metabolites in lung cancer: A meta-analysis.

Background: The diagnosis of lung cancer is based on the microscopic exam of tissue or liquid. During the recent decade, many biomarkers have been pointed to have a potential diagnostic role. These biomarkers may be assessed in blood, pleural effusion or sputum and they could avoid biopsies or other risky procedures. The authors aimed to assess the diagnostic performances of biomarkers focusing on micro-RNA and metabolites.

Methods: This meta-analysis was conducted under the PRISMA guidelines during a nine-year-period (2013-2022). the Meta-Disc software 5.4 (free version) was used. Q test and I2 statistics were carried out to explore the heterogeneity among studies. Meta-regression was performed in case of significant heterogeneity. Publication bias was assessed using the funnel plot test and the Egger's test (free version JASP).

Results: According to our inclusion criteria, 165 studies from 79 articles were included. The pooled SEN, SPE and dOR accounted, respectively, for 0.76, 0.79 and 13.927. The AUC was estimated to 0.859 suggesting a good diagnostic accuracy. The heterogeneity in the pooled SEN and SPE was statistically significant. The meta-regression analysis focusing on the technique used, the sample, the number of biomarkers, the biomarker subtype, the tumor stage and the ethnicity revealed the biomarker number (p  =  0.009) and the tumor stage (p  =  0.0241) as potential sources of heterogeneity.

Conclusion: Even if this meta-analysis highlighted the potential diagnostic utility of biomarkers, more prospective studies should be performed, especially to assess the biomarkers' diagnostic potential in early-stage lung cancers.

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来源期刊
CiteScore
1.30
自引率
0.00%
发文量
78
期刊介绍: The Asian Cardiovascular and Thoracic Annals is an international peer-reviewed journal pertaining to cardiovascular and thoracic medicine. Besides original clinical manuscripts, we welcome research reports, product reviews, reports of new techniques, and findings of special significance to Asia and the Pacific Rim. Case studies that have significant novel original observations, are instructive, include adequate methodological details and provide conclusions. Workshop proceedings, meetings and book reviews, letters to the editor, and meeting announcements are encouraged along with relevant articles from authors.
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