巴基斯坦鸽子中新城疫病毒的地理分布和遗传多样性。

IF 2.5 2区 农林科学 Q1 VETERINARY SCIENCES Avian Pathology Pub Date : 2024-04-01 Epub Date: 2024-01-25 DOI:10.1080/03079457.2023.2291107
Abdul Wajid, Quratulain Maqsood, Mourad Ben Said, Shahid Sherzada, Mohammed Nooruzzaman, Andleeb Batool, Renfu Yin, Mahmoud Sabra, Atif Hanif, Muhammad Azam Kakar, Tanveer Hussain, Nazeer Ahmed
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引用次数: 0

摘要

摘要新城疫病毒(NDV)是禽类中最重要的病毒之一,但其变异也可引起鸡科鸟类的临床疾病。从2014年起,在赛鸽和岩鸽中观察到显著的死亡率,这与巴基斯坦基因型XXI的XXI.1.1和XXI.1.2亚基因型相关。本研究对29株鸽子源NDV分离株进行了分离和遗传鉴定,这些分离株亚基因型分别为XXI.1.1、XXI.1.2和VII.2。基于全融合基因序列的系统发育分析将7株分离株划分为XXI.1.1亚基因型,与2005 - 2018年在巴基斯坦(0.05 ~ 0.43%核苷酸差异)和伊朗、俄罗斯、埃及、尼日利亚、哈萨克斯坦和乌克兰(3.75% ~ 6.67%核苷酸差异)鉴定的分离株遗传亲缘关系密切。此外,19株(n = 19)分离株与先前在巴基斯坦分离的病毒(2014-2018年)聚集在一起,亚基因型为XXI.1.2。此外,已鉴定出3个(n = 3)属于亚基因型VII.2的f基因序列,以及从巴基斯坦的几种家禽和非家禽鸟类中反复分离(2011-2020年)的病毒。根据脑内致病性指数(ICPI)分析,XXI.1.1和XXI.1.2亚基因型分离株均为中致病性(1.42 ~ 1.49),而VII.2亚基因型分离株为致病性(1.63 ~ 1.71)。本研究提供了自2014年以来巴基斯坦XXI.1.1和XXI.1.2亚基因型患病率的全面写照。此外,它强调了自由放养的鸽子作为毒性亚基因型VII.2病毒的有效携带者的作用,影响在开放环境中饲养的家禽和非家禽鸟类。
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Geographic distribution and genetic diversity of Newcastle disease virus in pigeons from Pakistan.

Research highlights: Virulent NDV genotypes were repeatedly isolated from pigeons.Evidence of epidemiological links among viruses isolated from various locations.Distinct phylogenetic branches suggest separate, simultaneous evolution of NDVs.Study information could be helpful in the development of an effective vaccine.

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来源期刊
Avian Pathology
Avian Pathology 农林科学-兽医学
CiteScore
4.50
自引率
10.70%
发文量
68
审稿时长
1 months
期刊介绍: Avian Pathology is the official journal of the World Veterinary Poultry Association and, since its first publication in 1972, has been a leading international journal for poultry disease scientists. It publishes material relevant to the entire field of infectious and non-infectious diseases of poultry and other birds. Accepted manuscripts will contribute novel data of interest to an international readership and will add significantly to knowledge and understanding of diseases, old or new. Subject areas include pathology, diagnosis, detection and characterisation of pathogens, infections of possible zoonotic importance, epidemiology, innate and immune responses, vaccines, gene sequences, genetics in relation to disease and physiological and biochemical changes in response to disease. First and subsequent reports of well-recognized diseases within a country are not acceptable unless they also include substantial new information about the disease or pathogen. Manuscripts on wild or pet birds should describe disease or pathogens in a significant number of birds, recognizing/suggesting serious potential impact on that species or that the disease or pathogen is of demonstrable relevance to poultry. Manuscripts on food-borne microorganisms acquired during or after processing, and those that catalogue the occurrence or properties of microorganisms, are unlikely to be considered for publication in the absence of data linking them to avian disease.
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