miRNA生物发生与衰变研究进展。

IF 3.6 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY RNA Biology Pub Date : 2024-01-01 Epub Date: 2023-11-29 DOI:10.1080/15476286.2023.2288741
Xavier Bofill-De Ros, Ulf Andersson Vang Ørom
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引用次数: 0

摘要

MicroRNAs是一类小的调节rna,通过识别mrna中的序列元件介导蛋白质合成的调节。microrna的加工经历了一系列的步骤,从细胞核中的转录和初级加工到细胞质中的前体加工和成熟功能。在细胞质中,成熟microrna的水平也可以通过衰变机制进行调节。在这里,我们回顾了microRNA生命周期中维持其稳态所需的所有步骤的最新进展。随着对microRNA调控知识的不断增加,microRNA作为治疗靶点具有很大的前景。
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Recent progress in miRNA biogenesis and decay.

MicroRNAs are a class of small regulatory RNAs that mediate regulation of protein synthesis by recognizing sequence elements in mRNAs. MicroRNAs are processed through a series of steps starting from transcription and primary processing in the nucleus to precursor processing and mature function in the cytoplasm. It is also in the cytoplasm where levels of mature microRNAs can be modulated through decay mechanisms. Here, we review the recent progress in the lifetime of a microRNA at all steps required for maintaining their homoeostasis. The increasing knowledge about microRNA regulation upholds great promise as therapeutic targets.

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来源期刊
RNA Biology
RNA Biology 生物-生化与分子生物学
CiteScore
8.60
自引率
0.00%
发文量
82
审稿时长
1 months
期刊介绍: RNA has played a central role in all cellular processes since the beginning of life: decoding the genome, regulating gene expression, mediating molecular interactions, catalyzing chemical reactions. RNA Biology, as a leading journal in the field, provides a platform for presenting and discussing cutting-edge RNA research. RNA Biology brings together a multidisciplinary community of scientists working in the areas of: Transcription and splicing Post-transcriptional regulation of gene expression Non-coding RNAs RNA localization Translation and catalysis by RNA Structural biology Bioinformatics RNA in disease and therapy
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