鲍曼不动杆菌的致病性和毒性:医疗机构和受感染宿主的致病因素。

IF 5.5 1区 农林科学 Q1 IMMUNOLOGY Virulence Pub Date : 2024-12-01 Epub Date: 2023-12-06 DOI:10.1080/21505594.2023.2289769
Massimiliano Lucidi, Daniela Visaggio, Antonella Migliaccio, Giulia Capecchi, Paolo Visca, Francesco Imperi, Raffaele Zarrilli
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引用次数: 0

摘要

鲍曼不动杆菌是造成医疗相关性感染和医院疫情爆发的常见原因,尤其是在重症监护病房。鲍曼不动杆菌的成功在很大程度上取决于其基因组的可塑性,这种可塑性使其能够迅速适应逆境和压力。获得新型抗生素耐药性决定因子的能力和对医院环境中遇到的压力的耐受性促进了鲍曼不动杆菌在患者中的传播和对医疗环境的长期污染。本综述探讨了导致鲍曼不动杆菌感染和适应医院环境的毒力因子和生理特征。鲍曼不动杆菌生物膜的形成、细胞粘附、入侵和在宿主体内的持续存在,以及对医疗环境造成的干旱胁迫的抵抗力,都涉及到一些细胞相关和分泌的毒力因子,本文对这些毒力因子进行了阐述,以说明鲍曼不动杆菌成功成为医院病原体的原因。
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Pathogenicity and virulence of Acinetobacter baumannii: Factors contributing to the fitness in healthcare settings and the infected host.

Acinetobacter baumannii is a common cause of healthcare-associated infections and hospital outbreaks, particularly in intensive care units. Much of the success of A. baumannii relies on its genomic plasticity, which allows rapid adaptation to adversity and stress. The capacity to acquire novel antibiotic resistance determinants and the tolerance to stresses encountered in the hospital environment promote A. baumannii spread among patients and long-term contamination of the healthcare setting. This review explores virulence factors and physiological traits contributing to A. baumannii infection and adaptation to the hospital environment. Several cell-associated and secreted virulence factors involved in A. baumannii biofilm formation, cell adhesion, invasion, and persistence in the host, as well as resistance to xeric stress imposed by the healthcare settings, are illustrated to give reasons for the success of A. baumannii as a hospital pathogen.

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来源期刊
Virulence
Virulence IMMUNOLOGY-MICROBIOLOGY
CiteScore
9.20
自引率
1.90%
发文量
123
审稿时长
6-12 weeks
期刊介绍: Virulence is a fully open access peer-reviewed journal. All articles will (if accepted) be available for anyone to read anywhere, at any time immediately on publication. Virulence is the first international peer-reviewed journal of its kind to focus exclusively on microbial pathogenicity, the infection process and host-pathogen interactions. To address the new infectious challenges, emerging infectious agents and antimicrobial resistance, there is a clear need for interdisciplinary research.
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