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引用次数: 0
摘要
乳腺癌是一种严重危及妇女生命的恶性肿瘤。不同分子类型的乳腺癌患者预后不同。与其他亚型相比，三阴性乳腺癌(triple negative breast cancer, TNBC)因其恶性程度高、侵袭性强、进展快、易复发、远处转移、预后差、死亡率高等特点，成为近年来的研究热点。许多研究发现，长链非编码RNA (long non-coding RNA, lncRNA)在TNBC的发生、增殖、迁移、复发、化疗耐药等特征中发挥着重要作用。一些lncrna有望成为TNBC诊断和预后的生物标志物，甚至成为TNBC治疗的新靶点。本文在检索PubMed文献的基础上，综述了lncrna在TNBC中的研究进展，并探讨了lncrna在TNBC诊断、预后及化疗中的作用，希望能为今后的研究提供帮助。
Roles of lncRNA in the diagnosis and prognosis of triple-negative breast cancer.
Breast cancer is a malignant tumor that seriously endangers women's lives. The prognosis of breast cancer patients differs among molecular types. Compared with other subtypes, triple-negative breast cancer (TNBC) has been a research hotspot in recent years because of its high degree of malignancy, strong invasiveness, rapid progression, easy of recurrence, distant metastasis, poor prognosis, and high mortality. Many studies have found that long non-coding RNA (lncRNA) plays an important role in the occurrence, proliferation, migration, recurrence, chemotherapy resistance, and other characteristics of TNBC. Some lncRNAs are expected to become biomarkers in the diagnosis and prognosis of TNBC, and even new targets for its treatment. Based on a PubMed literature search, this review summarizes the progress in research on lncRNAs in TNBC and discusses their roles in TNBC diagnosis, prognosis, and chemotherapy with the hope of providing help for future research.
期刊介绍：
Journal of Zheijang University SCIENCE B - Biomedicine & Biotechnology is an international journal that aims to present the latest development and achievements in scientific research in China and abroad to the world’s scientific community.
JZUS-B covers research in Biomedicine and Biotechnology and Biochemistry and topics related to life science subjects, such as Plant and Animal Sciences, Environment and Resource etc.
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