Minchen Dai , Biwei Shi , Xian Zhang , Yinger Gu , Fangfang Wang , Jue Zhou , Fan Qu
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The clinical data were collected from the medical records of the included patients. Bone morphogenetic protein 15 (BMP15) and leukemia inhibitory factor levels in the follicular fluids were detected.</p></div><div><h3>Results</h3><p>After the treatment of Bu-Shen-Jian-Pi Formula, women with PCOS undergoing IVF-ET exhibited significant improvement in the fertilization (P<0.05), good-quality embryo (P<0.01), clinical pregnancy (P<0.01), and live birth (P<0.01) rates, and single birthweight in newborns (P<0.05). 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引用次数: 0
摘要
中药被广泛用于治疗多囊卵巢综合征(PCOS)。本研究旨在通过回顾性队列研究，探讨补肾健脾方对PCOS患者体外受精和胚胎移植(IVF-ET)妊娠结局的影响。方法选取2016年7月至2021年6月在浙江大学医学院附属女子医院接受IVF-ET治疗的146例女性PCOS患者，其中73例患者在IVF-ET前12周接受补参健脾方治疗，73例患者未接受治疗。临床资料从纳入患者的病历中收集。检测卵泡液中骨形态发生蛋白15 (Bone morphogenetic protein 15, BMP15)和白血病抑制因子水平。结果经补肾健脾方治疗后，经IVF-ET治疗的PCOS患者受精率(P<0.05)、优质胚胎率(P<0.01)、临床妊娠率(P<0.01)、活产率(P<0.01)和新生儿单胎体重(P<0.05)均有显著提高。补肾健脾方治疗后，PCOS患者卵泡液中BMP15的表达水平显著升高(p < 0.05)。结论本研究为补参健脾方治疗与PCOS患者IVF-ET妊娠结局的显著改善提供了初步证据，部分原因是通过提高卵泡液BMP15水平。
Effects of Chinese herbal medicine on pregnancy outcomes of women with PCOS undergoing in vitro fertilization and embryo transfer: A retrospective cohort study
Introduction
Chinese herbal medicine is widely used for treating polycystic ovary syndrome (PCOS). The present study aimed to explore the effects of Bu-Shen-Jian-Pi Formula, a Chinese herbal medicine formula, on the pregnancy outcomes of women with PCOS undergoing in vitro fertilization and embryo transfer (IVF-ET) based on a retrospective cohort study.
Methods
One hundred and forty-six females with PCOS undergoing IVF-ET were included in the study from Women's Hospital, School of Medicine, Zhejiang University between July 2016 and June 2021, of whom 73 patients received Bu-Shen-Jian-Pi Formula treatment for 12 weeks before IVF-ET, while the other 73 did not. The clinical data were collected from the medical records of the included patients. Bone morphogenetic protein 15 (BMP15) and leukemia inhibitory factor levels in the follicular fluids were detected.
Results
After the treatment of Bu-Shen-Jian-Pi Formula, women with PCOS undergoing IVF-ET exhibited significant improvement in the fertilization (P<0.05), good-quality embryo (P<0.01), clinical pregnancy (P<0.01), and live birth (P<0.01) rates, and single birthweight in newborns (P<0.05). The expression levels of BMP15 in the follicular fluids of the women with PCOS were significantly increased after Bu-Shen-Jian-Pi Formula treatment (P<0.05).
Conclusion
This study provided preliminary evidence of a significant association of Bu-Shen-Jian-Pi Formula treatment with improved pregnancy outcomes in women with PCOS undergoing IVF-ET, partly through increasing BMP15 levels in the follicular fluids.
期刊介绍：
The European Journal of Integrative Medicine (EuJIM) considers manuscripts from a wide range of complementary and integrative health care disciplines, with a particular focus on whole systems approaches, public health, self management and traditional medical systems. The journal strives to connect conventional medicine and evidence based complementary medicine. We encourage submissions reporting research with relevance for integrative clinical practice and interprofessional education.
EuJIM aims to be of interest to both conventional and integrative audiences, including healthcare practitioners, researchers, health care organisations, educationalists, and all those who seek objective and critical information on integrative medicine. To achieve this aim EuJIM provides an innovative international and interdisciplinary platform linking researchers and clinicians.
The journal focuses primarily on original research articles including systematic reviews, randomized controlled trials, other clinical studies, qualitative, observational and epidemiological studies. In addition we welcome short reviews, opinion articles and contributions relating to health services and policy, health economics and psychology.
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