Synthesis, synthetic interests, and biological activities of β-substituted vinylphosphonates

β-Substituted vinylphosphonates constitute an original class of organophosphorus reagents of which several compounds exhibit attractive biological properties. The review exemplifies and discusses the different synthetic methods described for their synthesis, which involve well known reactions, but also more specifically designed methods. In addition, the uses as synthetic intermediates as well as the therapeutic uses of the title compounds are also summarized.