叶酸缺乏饮食和5-氟尿嘧啶治疗对L1210白血病小鼠zn - VlVO模型的影响

IF 0.5 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Pteridines Pub Date : 2020-05-26 DOI:10.1515/pteridines.1994.5.3.107
Julita Graczyk
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引用次数: 0

摘要

本研究探讨了饮食不足导致机体内叶酸含量降低对氟脲嘧啶治疗L1210白血病小鼠存活时间的影响。氟尿嘧啶细胞毒性作用的机制之一是通过结合5-氟尿嘧啶代谢物氟脱氧尿苷酸抑制胸苷酸合成酶。以叶酸为底物的四氢叶烷因子参与了这一过程。本研究表明,不添加叶酸的合成饲粮可显著降低血清叶酸水平,降低维生素b2水平,导致贫血和白细胞计数降低。氟尿嘧啶对L1210白血病的抗肿瘤作用在该组小鼠中弱于在满足叶酸需求的合成饲料小鼠中氟尿嘧啶的作用。
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Effect of Folate-deficient Diet and 5-Fluorouracil Treatment In the zn VlVO Model of Mice L1210 Leukemia
SummaryThe present study investigated the effect of reduced folic acid content in the organism, due to deficient diet, on the survival time of mice with L1210 leukemia, treated with fluorouracil. One of the mechanisms of the cytotoxic effect of fluorouracil is the inhibition of thymidylate synthase by binding fluorodeoxyuridylate, a 5-fluorouracil metabolite. Tetrahydrofoliane factor, for which folic acid is the substrate, takes part in this process. From the presented study it follows that the synthetic diet prepared without the addition of folic acid caused significantly lower blood serum folic acid levels, reduction of vitamin Bl2 level, anemia, as well as lowered leukocyte count. The antineoplastic effect of fluorouracil on L1210 leukemia was in that group of mice weaker than the effect of fluorouracil in mice receiving synthetic diet which met their folic acid requirement.
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来源期刊
Pteridines
Pteridines 生物-生化与分子生物学
CiteScore
1.20
自引率
25.00%
发文量
6
审稿时长
>12 weeks
期刊介绍: Pteridines is an open acess international quarterly journal dealing with all aspects of pteridine research. Pteridines are heterocyclic fused ring compounds involved in a wide range of biological functions from the color on butterfly wings to cofactors in enzyme catalysis to essential vitamins. Of the pteridines, 5,6,7,8-tetrahydrobiopterin is the necessary cofactor of several aromatic amino acid monoxygenases, the nitric oxide synthases and glyceryl ether monoxygenase (GEMO). Neopterin plays an essential role in the immune system and is an important biomarker in laboratory medicine for diseases such as HIV, cardiovascular disease, malignant tumors, among others. Topics: -Neopterin, dihydroneopterin, monapterin- Biopterin, tetrahydrobiopterin- Folates, antifolates, riboflavin- Phenylalanine, tyrosine, phenylketonuria, serotonin, adrenalin, noradrenalin, L-DOPA, dopamine, related biogenic amines- Phenylalanine hydroxylase, tyrosine hydroxylase, tryptophan hydroxylase, nitric oxide synthases (iNOS), alkylglycerol monooxygenase (AGMO), dihydropterin reductase, sepiapterin reductase- Homocysteine, mediators of inflammation, redox systems, iron.
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