纳米级单颗粒发光成像/检测:最新技术与未来展望

IF 4.6 Q1 CHEMISTRY, ANALYTICAL ACS Measurement Science Au Pub Date : 2023-12-07 DOI:10.1021/acsmeasuresciau.3c00052
Muhammad Saqib*, Mariam Zafar, Mohamed Ibrahim Halawa, Shahzad Murtaza, Ghulam Mustafa Kamal and Guobao Xu, 
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引用次数: 0

摘要

在反应过程中进行单颗粒级测量,可避免传统集合策略固有限制的平均效应。它通过考虑关键的粒子选择性描述因子,包括结构/形态动态、内在异质性和反应性(动力学、机理)的动态波动,揭示了平均特性之外的结构-活性关系。近年来,化学发光(CL)、电化学发光(ECL)和荧光(FL)显微镜等多种发光(光学)技术因其光谱原理多样化、非侵入性、灵敏度高和足够的时空分辨率而逐渐成为实现此类测量的主要工具。相应地,最先进的方法和工具正被用于探测(实时、操作、原位)单颗粒在传感、医学和催化方面的各种应用。在此,我们将通过特别强调单颗粒的基本原理、机理途径、进展、挑战和关键应用,简明而全面地透视基于发光的单颗粒检测和成像。本视角侧重于基于发射强度和成像的单颗粒检测的发展。此外,还记录了传感、运动、催化、能源、材料等领域的几个关键实例,以及相关领域的新兴趋势。最后,我们总结了该领域进一步发展所面临的机遇和挑战。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Nanoscale Luminescence Imaging/Detection of Single Particles: State-of-the-Art and Future Prospects

Single-particle-level measurements, during the reaction, avoid averaging effects that are inherent limitations of conventional ensemble strategies. It allows revealing structure–activity relationships beyond averaged properties by considering crucial particle-selective descriptors including structure/morphology dynamics, intrinsic heterogeneity, and dynamic fluctuations in reactivity (kinetics, mechanisms). In recent years, numerous luminescence (optical) techniques such as chemiluminescence (CL), electrochemiluminescence (ECL), and fluorescence (FL) microscopies have been emerging as dominant tools to achieve such measurements, owing to their diversified spectroscopy principles, noninvasive nature, higher sensitivity, and sufficient spatiotemporal resolution. Correspondingly, state-of-the-art methodologies and tools are being used for probing (real-time, operando, in situ) diverse applications of single particles in sensing, medicine, and catalysis. Herein, we provide a concise and comprehensive perspective on luminescence-based detection and imaging of single particles by putting special emphasis on their basic principles, mechanistic pathways, advances, challenges, and key applications. This Perspective focuses on the development of emission intensities and imaging based individual particle detection. Moreover, several key examples in the areas of sensing, motion, catalysis, energy, materials, and emerging trends in related areas are documented. We finally conclude with the opportunities and remaining challenges to stimulate further developments in this field.

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来源期刊
ACS Measurement Science Au
ACS Measurement Science Au 化学计量学-
CiteScore
5.20
自引率
0.00%
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0
期刊介绍: ACS Measurement Science Au is an open access journal that publishes experimental computational or theoretical research in all areas of chemical measurement science. Short letters comprehensive articles reviews and perspectives are welcome on topics that report on any phase of analytical operations including sampling measurement and data analysis. This includes:Chemical Reactions and SelectivityChemometrics and Data ProcessingElectrochemistryElemental and Molecular CharacterizationImagingInstrumentationMass SpectrometryMicroscale and Nanoscale systemsOmics (Genomics Proteomics Metabonomics Metabolomics and Bioinformatics)Sensors and Sensing (Biosensors Chemical Sensors Gas Sensors Intracellular Sensors Single-Molecule Sensors Cell Chips Arrays Microfluidic Devices)SeparationsSpectroscopySurface analysisPapers dealing with established methods need to offer a significantly improved original application of the method.
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