5-/12 脂氧合酶-BLT2 级联反应诱导 c-Myc 表达升高，从而介导 KRAS 突变结直肠癌细胞的增殖和迁移

IF 2.5 2区生物学 Q3 CELL BIOLOGY Animal Cells and Systems Pub Date : 2023-12-11 DOI:10.1080/19768354.2023.2290031

Jaein Park, Jae-Hyun Jang, Jun-Dong Wei, Jae-Hong Kim

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引用次数: 0

摘要

结肠直肠癌（CRC）是最常见的恶性肿瘤，也是全球癌症相关死亡的主要原因之一。癌基因 KRAS 是 CRC 中常见的突变基因，在 CRC 的发生和发展过程中起着至关重要的作用。

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The 5-/12-lipoxygenase-BLT2 cascade induces elevated expression of c-Myc, thus mediating the proliferation and migration of KRAS mutant colorectal cancer cells

Colorectal cancer (CRC) is the most common malignant tumor and one of the leading causes of cancer-related death worldwide. Oncogene KRAS is a commonly mutated in CRC and plays crucial roles in the...

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来源期刊

Animal Cells and Systems 生物-动物学

CiteScore

4.50

自引率

24.10%

发文量

审稿时长

6 months

期刊介绍： Animal Cells and Systems is the official journal of the Korean Society for Integrative Biology. This international, peer-reviewed journal publishes original papers that cover diverse aspects of biological sciences including Bioinformatics and Systems Biology, Developmental Biology, Evolution and Systematic Biology, Population Biology, & Animal Behaviour, Molecular and Cellular Biology, Neurobiology and Immunology, and Translational Medicine.