Morphological Changes in Erythrocytes of Newborns after Perinatal Hypoxia

Abstract

Despite the active research that has taken place on the functional properties of erythrocytes under pathological conditions, this issue is quite relevant. One of the causes of fetal and newborn distress is hypoxia. The consequences of the negative impact of oxygen deficiency on the embryo and fetus can manifest themselves both in utero and after birth, leading to various diseases. The aim of this work was to study the effect of acidosis, as a marker of perinatal hypoxia, on the membrane of erythrocytes in newborns of the early neonatal period. The use of an atomic-force microscope allowed us to obtain cell images and profiles to assess the morphological and structural features of erythrocytes during hypoxia in children in the early neonatal period. It was established that perinatal hypoxia causes changes in the morphology and structures of erythrocyte membranes. The early neonatal period is characterized by changes in morphological forms and the instability of erythrocyte membranes.