艾滋病毒共受体趋向性的使用：伊朗患者的首次报告

IF 2.1 4区医学 Q3 VIROLOGY Future Virology Pub Date : 2023-12-01 DOI:10.2217/fvl-2023-0034

F. Ghasabi, Ava Hashempour, N. Khodadad, Shokufeh Akbarinia, Mohammadreza Heydari, Z. Foroozanfar

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引用次数: 0

摘要

目的:HIV- v3序列通过与CCR5和CXCR4共受体的相互作用影响趋向性;然而，没有一致的序列解释R5或x4病毒。方法:采用gen2pheno、WebPSSM、PhenoSeq、Net Charge和11/25规则等基因分型方法，对123份样品进行rt -巢式PCR鉴定向v3性。结果:在所研究的样本中，HIV-1 R5热带病毒占主导地位。然而，X4趋向性可能是治疗失败风险较高的一个原因。配对的DNA/RNA趋向性结果具有良好的一致性。结论:CCR5抑制剂对于简化伊朗HIV患者的治疗至关重要。x4病毒是治疗失败的一个危险因素。前病毒DNA (pvDNA)的趋向性结果可作为测定病毒向v3趋向性的合适靶点。

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HIV co-receptor tropism usage: first report from the Iranian patients

Aim: The HIV-V3 sequence influences tropism via the interaction of HIV with CCR5 and CXCR4 coreceptors; however, no consistent sequence accounts for R5 or X4-virus. Methods: RT-Nested PCR was performed to define V3-tropism in 123 samples using genotypic methods, including Geno2Pheno, WebPSSM, PhenoSeq, Net Charge and the 11/25 rule. Results: Among the samples studied, the HIV-1 R5 tropic viruses were predominant. However, X4 tropism could be a reason for the higher risk of treatment failure. A good accordance was observed between paired DNA/RNA tropism results. Conclusion: CCR5 inhibitors can be crucial in simplifying HIV treatment in Iranian patients. X4-virus is a risk factor for treatment failure. Proviral DNA (pvDNA) tropism result can be an appropriate target for V3-tropism determination.

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来源期刊

Future Virology 医学-病毒学

CiteScore

4.00

自引率

3.20%

发文量

审稿时长

6-12 weeks

期刊介绍： Future Virology is a peer-reviewed journal that delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for this ever-expanding area of research. It is an interdisciplinary forum for all scientists working in the field today.