循环细胞因子特征作为非小细胞肺癌免疫检查点抑制剂疗法的可溶性生物标记物

IF 5 3区 医学 Q1 GENETICS & HEREDITY Genes and immunity Pub Date : 2023-12-14 DOI:10.1038/s41435-023-00236-5
Feifei Wei, Tetsuro Sasada
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引用次数: 0

摘要

以非小细胞肺癌(NSCLC)为代表的肺癌仍然是全球范围内癌症相关死亡的主要原因[1]。近年来,免疫检查点抑制剂(ici)越来越多地用于非小细胞肺癌的治疗,具有可接受的安全性和有效性。然而,ICIs产生不同的应答率,当根据程序性死亡配体1 (PD-L1)表达选择时,不到40%的个体显示出积极的应答。因此,迫切需要预测性生物标志物。分析肿瘤组织样本通常是大多数临床批准的生物标志物的要求,这可能无法有效预测非小细胞肺癌ICI治疗的治疗结果和患者生存率。可溶性生物标志物以微创的方式在肺癌的每个阶段提供实时监测,可重复性和易于实施的优点-从诊断到疾病进展。因此,迫切需要发现精确的可溶性生物标志物来预测非小细胞肺癌对ICI治疗的反应性[2]。细胞因子作为宿主免疫系统的可溶性介质,在肿瘤免疫治疗中发挥着重要作用。它们促进肿瘤浸润并重新激活肿瘤微环境中的效应淋巴细胞。直到最近,只有有限数量的细胞因子被单独评估,以预测小样本非小细胞肺癌患者的ICI治疗反应性。因此,我们对高维数据集采用了非线性机器学习方法,其中包括来自接受ICI治疗的患者的93种循环细胞因子。目的是确定具有预测价值的循环细胞因子特征,作为与NSCLC总生存期(OS)相关的生物标志物[3]。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Circulating cytokine signatures as a soluble biomarker of immune checkpoint inhibitor therapy in non-small-cell lung cancer
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来源期刊
Genes and immunity
Genes and immunity 医学-免疫学
CiteScore
8.90
自引率
4.00%
发文量
28
审稿时长
6-12 weeks
期刊介绍: Genes & Immunity emphasizes studies investigating how genetic, genomic and functional variations affect immune cells and the immune system, and associated processes in the regulation of health and disease. It further highlights articles on the transcriptional and posttranslational control of gene products involved in signaling pathways regulating immune cells, and protective and destructive immune responses.
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