增强黑色素瘤患者免疫疗法疗效的辅助微生物组疗法

IF 5 3区 医学 Q1 GENETICS & HEREDITY Genes and immunity Pub Date : 2023-12-13 DOI:10.1038/s41435-023-00240-9
John G. Lenehan, Saman Maleki Vareki
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引用次数: 0

摘要

在临床中,决定使用nivolumab和ipilimumab的组合是基于患者是否可能耐受已知的3/4级毒性的判断,这些毒性发生在超过一半的接受它的患者中。尽管如此,联合用药仍然是标准的治疗方法,其目标是优先使用,特别是颅内疾病患者。然而,目前尚不清楚哪些患者最终不需要添加抗ctla4,并且当与抗pd1联合使用时,可以避免与ctla4相关的毒性。MIMic试验的结果表明,基于微生物组的辅助干预可以改善对抗pd1单药治疗的反应,并且最小的额外毒性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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来源期刊
Genes and immunity
Genes and immunity 医学-免疫学
CiteScore
8.90
自引率
4.00%
发文量
28
审稿时长
6-12 weeks
期刊介绍: Genes & Immunity emphasizes studies investigating how genetic, genomic and functional variations affect immune cells and the immune system, and associated processes in the regulation of health and disease. It further highlights articles on the transcriptional and posttranslational control of gene products involved in signaling pathways regulating immune cells, and protective and destructive immune responses.
期刊最新文献
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