环状 RNA 在男性不育症和生殖系统癌症中的作用:叙述性综述。

IF 1.6 Q2 MEDICINE, GENERAL & INTERNAL Iranian Journal of Medical Sciences Pub Date : 2023-11-01 DOI:10.30476/IJMS.2022.95302.2661
Zahra Derakhshan, Soghra Bahmanpour, Sanaz Alaee, Jafar Fallahi, Seyed Mohammad Bagher Tabei
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引用次数: 0

摘要

不孕不育是一个全球性的健康问题,影响着约 15%的夫妇,其中 50%是由于男性不育造成的。虽然大多数不育男性的不育病因已明,但特发性男性不育仍是一个难题。因此,需要新的诊断方法来检测其潜在机制并开发适当的疗法。最近的研究集中于非编码 RNA(ncRNA)在男性不育中的作用。环状 RNA(CircRNA)是 ncRNA 的一种,在心血管疾病、糖尿病、癌症、自身免疫性疾病等病症的发生发展中起着关键作用。一些研究报告称,CircRNAs 及其靶基因存在于人类生殖系统中。此外,它们在睾丸组织、精子细胞和精液中的表达也已被确定。CircRNAs 的异常表达与不育男性的无精子症和无精子症有关。本综述简要介绍了 CircRNAs 在生精细胞、男性不育症和生殖系统癌症中的作用。此外,一些 CircRNAs 已被确定为检测和治疗疾病的潜在生物标志物。
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The Role of Circular RNAs in Male Infertility and Reproductive Cancers: A Narrative Review.

Infertility is a global health problem affecting about 15% of all couples, of which 50% are due to male infertility. Although the etiology of infertility is known in most infertile men, idiopathic male infertility remains a challenge. Therefore, there is a need for novel diagnostic methods to detect the underlying mechanisms and develop appropriate therapies. Recent studies have focused on the role of non-coding RNAs (ncRNAs) in male infertility. Circular RNAs (CircRNAs), a type of ncRNAs, are found to play a key role in the development of some pathological conditions, including cardiovascular diseases, diabetes, cancers, autoimmune diseases, etc. Several studies have reported the presence of CircRNAs and their target genes in the human reproductive system. In addition, their expression in testicular tissues, sperm cells, and seminal fluid has been identified. Abnormal expression of CircRNAs has been associated with azoospermia and asthenozoospermia in infertile men. The present narrative review provides a brief description of the role of CircRNAs in spermatogenic cells, male infertility, and reproductive cancers. In addition, some CircRNAs have been identified as potential biomarkers for disease detection and treatment.

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来源期刊
Iranian Journal of Medical Sciences
Iranian Journal of Medical Sciences MEDICINE, GENERAL & INTERNAL-
CiteScore
3.20
自引率
0.00%
发文量
84
审稿时长
12 weeks
期刊介绍: The Iranian Journal of Medical Sciences (IJMS) is an international quarterly biomedical publication, which is sponsored by Shiraz University of Medical Sciences. The IJMS intends to provide a scientific medium of com­muni­cation for researchers throughout the globe. The journal welcomes original clinical articles as well as clinically oriented basic science re­search experiences on prevalent diseases in the region and analysis of various regional problems.
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