第二部分:希夫碱合成及在药物化学中应用的最新进展--专利回顾(2016-2023 年)。

IF 5.4 2区 医学 Q1 CHEMISTRY, MEDICINAL Expert Opinion on Therapeutic Patents Pub Date : 2023-12-01 Epub Date: 2024-01-15 DOI:10.1080/13543776.2023.2297729
Hafiza Amna Younus, Faiza Saleem, Abdul Hameed, Mariya Al-Rashida, Raed A Al-Qawasmeh, Mohamed El-Naggar, Sobia Rana, Muhammad Saeed, Khalid Mohammed Khan
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引用次数: 0

摘要

简介希夫碱是具有偶氮甲基连接(-C=N-)特征的化合物。希夫碱能够通过偶氮甲基氮与金属离子配位。希夫碱衍生物及其金属络合物具有引人入胜的新治疗特性。在有机合成中,希夫碱反应是生成 C-N 键的主要反应。通过醛/酮和伯胺之间的缩合反应轻松合成希夫碱杂化物的突出特点是合成的易得性和结构的多样性:本综述旨在全面概述2016年至2023年获得专利的希夫碱衍生物及其金属配合物的值得称道的医药应用:希夫碱衍生物是一种特殊的分子,在药物化学中有着各种各样的应用。有几种希夫碱产品已作为药物上市销售,而且在不同学科领域中,新化合物的目的性合成也有很大的空间。希夫碱衍生化的方向不计其数,应用领域也多种多样,这使它们成为 "神奇的分子"。从药物化学到医学以外的其他领域,这些化合物都被证明是非凡的。本综述涉及希夫碱衍生物在治疗方面的重要性,旨在介绍近年来(2016-2023 年)发表的专利。
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Part-II: an update of Schiff bases synthesis and applications in medicinal chemistry-a patent review (2016-2023).

Introduction: Schiff bases are compounds with characteristic features of azomethine linkage (-C=N-). Schiff bases are capable of coordinating with metal ions via azomethine nitrogen. Schiff base derivatives and their metal complexes are known for intriguing novel therapeutic properties. In organic synthesis, the Schiff base reaction is prime in creating the C-N bond. Synthetic accessibility and structural diversity are the salient features for facile synthesis of Schiff base hybrids via a condensation reaction between an aldehyde/ketone and primary amines.

Area covered: This review aims to provide a comprehensive overview of the commendable medicinal applications of Schiff base derivatives and their metal complexes patented from 2016 to 2023.

Expert opinion: Schiff base derivatives are exceptional molecules for their assorted applications in medicinal chemistry. Several Schiff base products are marketed as drugs, and plenty of room is available for the purposive synthesis of new compounds in a diverse pool of disciplines. Expansion in the derivatization of Schiff bases in innumerable directions with multitudinous applications makes them 'magical molecules.' These compounds have proved extraordinary, from medicinal chemistry to other fields outside medicine. This review covers the therapeutic importance of Schiff base derivatives and aims to cover the patents published in recent years (2016-2023).

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来源期刊
CiteScore
12.10
自引率
1.50%
发文量
50
审稿时长
6-12 weeks
期刊介绍: Expert Opinion on Therapeutic Patents (ISSN 1354-3776 [print], 1744-7674 [electronic]) is a MEDLINE-indexed, peer-reviewed, international journal publishing review articles on recent pharmaceutical patent claims, providing expert opinion the scope for future development, in the context of the scientific literature. The Editors welcome: Reviews covering recent patent claims on compounds or applications with therapeutic potential, including biotherapeutics and small-molecule agents with specific molecular targets; and patenting trends in a particular therapeutic area Patent Evaluations examining the aims and chemical and biological claims of individual patents Perspectives on issues relating to intellectual property The audience consists of scientists, managers and decision-makers in the pharmaceutical industry and others closely involved in R&D Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days.
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