朋友还是敌人？ANGPTL4 在炎症中难以捉摸的作用

Cell signaling Pub Date : 2023-12-21 DOI:10.46439/signaling.2.022

Yuyue Zuo, Yueqi Zhang, Lei Dai

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摘要

血管生成素样 4（ANGPTL4）属于血管生成素样蛋白家族，介导对脂蛋白脂肪酶活性的抑制。新的证据表明，ANGPTL4 具有抗炎和促炎的多重功能。在此，我们回顾了有关 ANGPTL4 的研究进展，并系统地讨论了 ANGPTL4 在炎症和炎症性疾病中的双重作用。了解 ANGPTL4 在炎症中的潜在机制将有助于药物发现和治疗开发。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Friend or foe? The elusive role of ANGPTL4 in inflammation

Angiopoietin-like 4 (ANGPTL4) belongs to the angiopoietin-like protein family and mediates the inhibition of lipoprotein lipase activity. Emerging evidence suggests that ANGPTL4 has pleiotropic functions with anti- and pro-inflammatory properties. Here, we have reviewed the research progress on ANGPTL4 and systematically discussed the dual role of ANGPTL4 in inflammation and inflammatory diseases. Understanding the potential mechanisms of ANGPTL4 in inflammation will aid in drug discovery and treatment development.

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Cell signaling

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