皮肤黑色素瘤的特征:紫外线以外的致癌因素

Lairane Bridi Loss, Juliana Casotti Santi, Sarah Aparecida Fernandes Lima, Mariana Santos Lorencini, Sabrina Chaves Costa Ferri, Rogério Pimentel Terra-Junior, Letícia Chiepe, Luiza Deleprani Stanger, Kelly Cristina Mota Braga Chiepe, Orlando Chiarelli-Neto
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摘要

黑色素瘤是最具侵袭性的皮肤癌,因为它具有转移潜力,近几十年来,其发病率大幅上升。日光中紫外线 A 和 B 的照射仍然是这种癌症发病的主要风险因素,但其他因素还包括家族史、人工晒黑、黑素细胞痣、低光型和可见光(VL)对黑色素的光敏作用。通过早期诊断发现恶性病变,可以及早开始治疗,从而提高存活率,降低总死亡率。免疫疗法和靶向疗法的进步改变了治疗模式,改善了晚期疾病的预后。由于该疾病在全球范围内的高发病率,本综述旨在描述皮肤黑色素瘤的特点(流行病学、病因学、病理生理学、临床、诊断、治疗、预后、预防和社会心理方面),如黑色素细胞对可见光(VL)的预防。
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CHARACTERIZATION OF CUTANEOUS MELANOMA: CARCINOGENESIS BEYOND ULTRAVIOLET LIGHT
Melanoma is the most aggressive type of skin cancer due to its metastatic potential, and its incidence has increased considerably in recent decades. Sun exposure to ultraviolet A and B irradiation remains the main risk factor for the development of this type of cancer, however, other factors involved are family history, artificial tanning, melanocytic nevi, and low phototype and feomelanin photosensitization by visible light (VL). Through early diagnostic detection of the malignant lesion, it is possible to initiate therapy in an early and curative way, increasing survival with a subsequent decrease in the overall mortality rate. Advances in immunotherapy and targeted therapy have changed treatment paradigms and improved the prognosis of late-stage disease. Due to the high prevalence of the disease worldwide, the purpose of this review was to characterize the cutaneous melanoma (epidemiology, etiology, pathophysiology, clinic, diagnosis, treatment, prognosis, prevention and  psychosocial aspects) such as prevention of the melanocytes against Visible Light (VL).
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