Potential role of the Sella Turcica x-ray imaging aspects for sex estimation in the field of Forensic anthropology: a systematic review and metanalysis

Several studies have evaluated the parameters of normality of the Sella Turcica (ST), which is important face to different craniofacial syndromes that may affect this structure. Therefore, this research summarized the scientific evidence on the role of ST in the sex estimation of non-syndromic individuals. The research protocol was registered (PROSPERO # CRD42021256469), followed by an electronic search in six databases (PubMed, LILACS, Web of Science, Scopus, EMBASE, LIVIVO) and gray literature (Google scholar, OpenGrey). Meta-analysis of linear (width, length, height, and diameter) and volumetric measurements, in addition to an assessment of risk of bias (RoB) and certainty of evidence, were performed. After the screening of 986 articles, 13 were evaluated by meta-analysis (1307 males and 1231 females). In subgroup analysis, females had lower values ​​for width (lateral radiograph; −0.67 mm; P = 0.040), length (computed tomography; −0.23 mm; P = 0.020), and diameter (computed tomography; −0.27 mm; P < 0.001) compared to males. There was no statistically significant difference regarding height (P = 0.95), area (P = 0.72), and volume (P = 0.21). Most studies exhibited moderate RoB, and the certainty of evidence of the outcomes was very low. In this review, significant differences were observed between the sexes for the length and diameter of the ST; however, the heterogeneity of the studies must be considered.