那不勒斯乙型肝炎病毒引起的慢性HBeAg阳性感染的中期自然病程。前瞻性研究，抗病毒治疗的初步研究]。

Minerva dietologica e gastroenterologica Pub Date : 1989-04-01

C Canestrini, L Amitrano, A Ascione, A De Lella, M De Luca, U Ferbo, E Riccio, T Gigliotti

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引用次数: 0

摘要

对41例连续观察的慢性乙肝病毒感染复制期(HBeAG阳性)患者进行平均60个月的随访，以评价自发性HBeAG /抗- hbe血清转化的频率及其对肝病临床病程的影响。41例患者，平均年龄22岁，发生ECP 26例，ECA 7例，CIRR 8例。18例患者(41%)出现HBeAg/anti-HBe血清转化，年转化率为12%，所有患者的肝细胞溶解试验均稳定正常化。与HBeAg/anti-HBe血清转化相关的因素为:女性、较高的转氨酶平均起始值、EVA阳性病史、无丁型病毒重复感染。只有当血清转化(抑制病毒复制)产生的频率比自发发生的频率高得多时，才能证明抗病毒治疗的有效性。指出了目前抗病毒治疗的候选药物。

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[Mid-term natural course in Naples of chronic HBeAg positive infection caused by the HB-virus. Prospective study, preliminary to antiviral treatment].

41 consecutively observed patients with chronic HB virus infection in replication phase (HBeAG positive) were followed up for an average period of 60 months with a view to evaluating the frequency of spontaneous HBeAg/anti-HBe seroconversion and the influence of the event on the clinical course of the liver disease. The 41 patients, of mean age 22 years, suffered from: 26 ECP, 7 ECA, 8 CIRR. 18 patients (41%) presented HBeAg/anti-HBe seroconversion with an annual percentage of 12%, all with stable normalisation of hepatic cytolysis tests. Factors related to HBeAg/anti-HBe seroconversion were: female sex, higher mean starting values of transaminase, positive history for EVA, absence of Virus Delta superinfection. The effectiveness of antiviral treatments will only be demonstrated when seroconversion (inhibition of viral replication) is produced much more frequently than that which occurs spontaneously. Candidates for current antiviral treatment are indicated.

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Minerva dietologica e gastroenterologica

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