新鲜卵母细胞与玻璃化卵母细胞的胚胎、遗传和临床结果:回顾性队列研究

IF 0.5 Q4 REPRODUCTIVE BIOLOGY Asian Pacific Journal of Reproduction Pub Date : 2023-12-01 DOI:10.4103/2305-0500.390301
Phuong Thi Dao, Son Truong Dang, Thuan Duc Nguyen, Anh Van Pham, Anh Tuan Do, Nguyen Van Hanh
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引用次数: 0

摘要

比较新鲜卵母细胞和冷冻解冻卵母细胞的胚胎发育、倍性状态和临床结果。 这项回顾性队列研究评估了越南海防国际产科和儿科医院 HP 生育中心 79 名患者的 83 个受精周期,包括新鲜和冷冻卵母细胞。患者接受了多个卵巢刺激周期,以积累一定数量的卵母细胞进行玻璃化处理。在最后一次取卵过程中,患者的所有卵母细胞(包括冷冻和新鲜卵母细胞)都将受精。结果包括卵母细胞存活率、卵裂胚胎率、囊胚率、倍性状态、妊娠率、生化妊娠率和临床妊娠率。 解冻后的卵母细胞存活率为 96.5%。新鲜卵母细胞和冷冻卵母细胞在受精率(78.1% 对 75.5%,P=0.461)和可用卵裂胚胎率(86.9% 对 87.2%,P=0.916)方面的差异无统计学意义,但冷冻卵母细胞组的可用囊胚率较高(44.4% 对 54.0%,P=0.049)。新鲜胚胎组和玻璃化胚胎组的非整倍体胚胎、非整倍体胚胎和马赛克胚胎的百分比没有显著差异(分别为 33.8% vs. 31.6%,P=0.682;51.0% vs. 54.2%,P=0.569;15.2% vs. 12.4%,P=0.787)。妊娠率、生化妊娠率和临床妊娠率无统计学差异(68.8% vs. 64.8%,P=0.764;12.5% vs. 3.6%,P=0.258;37.5% vs. 46.4%,P=0.565)。17 成熟卵母细胞至少要有一个单倍体胚胎。 卵母细胞玻璃化不会影响胚胎、遗传和临床结果。在某些情况下,受精时应考虑成熟卵母细胞的数量。
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Embryonic, genetic and clinical outcomes of fresh versus vitrified oocyte: A retrospective cohort study
To compare embryonic development, ploidy status and clinical outcomes between fresh and frozen-thawed oocytes. This retrospective cohort study evaluated 83 fertilization cycles including both fresh and frozen oocytes from 79 patients at the HP Fertility Center of Hai Phong International Hospital of Obstetrics and Pediatrics in Vietnam. The patient underwent several ovarian stimulation cycles to accumulate a certain number of oocytes that would be vitrified. In the last oocyte retrieval, all patient's oocytes including both frozen and fresh would be fertilized. The outcomes included the rates of oocyte survival, cleavage embryo, blastocyst, ploidy status, pregnancy, biochemical pregnancy and clinical pregnancy. The oocyte survival rate after thawing was 96.5%. No statistically significant difference was found when comparing fresh and frozen oocytes regarding fertilization rate (78.1% vs. 75.5%, P=0.461), usable cleavage embryo rate (86.9% vs. 87.2%, P=0.916) but usable blastocyst rate was found higher statistically in the frozen oocyte group (44.4% vs. 54.0%, P=0.049). The percentages of euploid, aneuploid and mosaic embryos between the fresh group and the vitrified group had no significant differences (33.8% vs. 31.6%, P=0.682; 51.0% vs. 54.2%, P=0.569; 15.2% vs. 12.4%, P=0.787; respectively). The rates of pregnancy, biochemical pregnancy and clinical pregnancy had no statistical difference (68.8% vs. 64.8%, P=0.764; 12.5% vs. 3.6%, P=0.258; 37.5% vs. 46.4%, P=0.565). 17 Mature oocytes are the minimum to have at least one euploid embryo. Oocyte vitrification does not affect embryonic, genetic and clinical results. The number of mature oocytes should be considered for fertilization in some cases.
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来源期刊
Asian Pacific Journal of Reproduction
Asian Pacific Journal of Reproduction Veterinary-Veterinary (all)
CiteScore
1.70
自引率
0.00%
发文量
588
审稿时长
9 weeks
期刊介绍: The journal will cover technical and clinical studies related to health, ethical and social issues in field of Gynecology and Obstetrics. Articles with clinical interest and implications will be given preference.
期刊最新文献
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