压力与皮肤:受机械压力驱动或影响的疾病实体综述

IF 8.6 1区 医学 Q1 DERMATOLOGY American Journal of Clinical Dermatology Pub Date : 2023-12-30 DOI:10.1007/s40257-023-00833-0
Wei-Chen Chien, Tsen-Fang Tsai
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引用次数: 0

摘要

皮肤能感知外部机械力并对其做出反应,从而产生抵御外部环境的能力。过度或不适当的压力刺激可能会导致皮肤细胞的改变,并引发良性和恶性皮肤疾病。我们进行了全面的文献综述,以深入研究压力诱发和加重的皮肤疾病及其与压力相关的内在机制。皮肤失调的机械反应会引起局部炎症、缺血、坏死、增生、角化过度、再生障碍、萎缩或其他损伤性反应,从而导致各种疾病。个人设备的使用、活动、职业、负重,甚至无意中的物体接触和姿势,都可能导致压力相关性皮肤病的发生。这些皮肤病可能涉及表皮(角质细胞和黑色素细胞)、毛囊、皮脂腺、甲器、真皮(成纤维细胞、肥大细胞和血管)、皮下和筋膜。明确每位患者的临床背景,认识到细胞和组织层面的压力是如何导致皮肤病变的,可以提高我们对压力相关皮肤疾病的理解,从而实现更好的管理。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Pressure and Skin: A Review of Disease Entities Driven or Influenced by Mechanical Pressure

Skin perceives and reacts to external mechanical forces to create resistance against the external environment. Excessive or inappropriate stimuli of pressure may lead to cellular alterations of the skin and the development of both benign and malignant skin disorders. We conducted a comprehensive literature review to delve into the pressure-induced and aggravated skin disorders and their underlying pressure-related mechanisms. Dysregulated mechanical responses of the skin give rise to local inflammation, ischemia, necrosis, proliferation, hyperkeratosis, impaired regeneration, atrophy, or other injurious reactions, resulting in various disease entities. The use of personal devices, activities, occupations, weight bearing, and even unintentional object contact and postures are potential scenarios that account for the development of pressure-related skin disorders. The spectrum of these skin disorders may involve the epidermis (keratinocytes and melanocytes), hair follicles, eccrine glands, nail apparatuses, dermis (fibroblasts, mast cells, and vasculature), subcutis, and fascia. Clarifying the clinical context of each patient and recognizing how pressure at the cellular and tissue levels leads to skin lesions can enhance our comprehension of pressure-related skin disorders to attain better management.

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来源期刊
CiteScore
15.20
自引率
2.70%
发文量
84
审稿时长
>12 weeks
期刊介绍: The American Journal of Clinical Dermatology is dedicated to evidence-based therapy and effective patient management in dermatology. It publishes critical review articles and clinically focused original research covering comprehensive aspects of dermatological conditions. The journal enhances visibility and educational value through features like Key Points summaries, plain language summaries, and various digital elements, ensuring accessibility and depth for a diverse readership.
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