Clinical significance of micronutrient status and vaginal microbiocenosis in pregnant women and correction of indentified disorders

Objective: to conduct a clinical analysis and evaluate the significance of micronutrient status and vaginal microbiocenosis in pregnant women and develop a method for correcting the identified disorders based on the use of Bellakt Mama+ powdered milk product.   Materials and methods. We conducted a prospective study on the basis of the professorial advisory center of the EE “Grodno State Medical University”. In the course of the work, we examined 110 pregnant women, 55 of whom took Bellakt MAMA + dry milk product for 3 months, and the second half were observed only according to the clinical protocol. The assessment was made: anamnestic - assessment of the anamnesis of life and disease; generally accepted clinical, laboratory and instrumental (ultrasound examination of the pelvic organs) research methods. Performed blood sampling from the cubital vein in the morning on an empty stomach with the determination of the levels of ferritin, calcium i, iron, total vitamin D, folic acid, osteocalcin. An assessment of the biocoenosis of the urogenital tract was carried out “Femoflor Screen”; statistical processing of the results was carried out.   Results. We found that in patients who took a dry dairy product of Belarusian production, a persistent positive trend in the increase in the level of folic acid (p = 0,0049), total vitamin D (p = 0,0041), serum iron (p = 0,0041) was established, ferritin (p = 0,0040), as well as improvement of the vaginal biocoenosis (p = 0,0040). There were no statistically significant differences in the levels of ionized calcium and osteocalcin. It should be noted that the patients of the main group had no complaints of discomfort in large joints, bones and cramps in the calf muscles, in contrast to the women of the control group.   Conclusion. The above results confirm the need to control and correct micronutrient deficiency and vaginal dysbiosis in women at the stage of preconception preparation and in the first trimester of pregnancy.