与年龄有关的α2-肾上腺素能受体刺激对大鼠心肌细胞电活动影响的特殊性

IF 4.033 Q4 Biochemistry, Genetics and Molecular Biology Biophysics Pub Date : 2023-12-13 DOI:10.1134/S0006350923040036

A. M. Galieva, N. I. Ziyatdinova, N. Mansour, L. I. Fashutdinov, T. L. Zefirov

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引用次数: 0

摘要

研究了盐酸氯尼丁（α2-肾上腺素能受体激动剂）对起搏时心房心肌电活动参数的影响。在成年大鼠体内，盐酸氯尼丁在起搏的工作心肌细胞中会导致动作电位持续时间缩短 50%和 90%。在 1 周龄和 3 周龄的大鼠中，这种激动剂会导致动作电位持续时间增加 50%和 90%。

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Age-Related Peculiarities of the Effect of Stimulation of α2-Adrenergic Receptors on the Electrical Activity of Rat Cardiomyocytes

The effect of clonidine hydrochloride (an agonist of α2-adrenergic receptors) on the parameters of electrical activity of the atrial myocardium during pacing was studied. Clonidine hydrochloride in working cardiomyocytes with pacing causes a decrease in the action potential duration at the level of 50 and 90% in adult rats. In 1- and 3-week-old rats, this agonist causes an increase in the action potential duration at the level of 50 and 90%.

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来源期刊

Biophysics Biochemistry, Genetics and Molecular Biology-Biophysics

CiteScore

1.20

自引率

0.00%

发文量

期刊介绍： Biophysics is a multidisciplinary international peer reviewed journal that covers a wide scope of problems related to the main physical mechanisms of processes taking place at different organization levels in biosystems. It includes structure and dynamics of macromolecules, cells and tissues; the influence of environment; energy transformation and transfer; thermodynamics; biological motility; population dynamics and cell differentiation modeling; biomechanics and tissue rheology; nonlinear phenomena, mathematical and cybernetics modeling of complex systems; and computational biology. The journal publishes short communications devoted and review articles.