硬脂作为合成生物活性离子液体的起始材料

IF 0.8 4区化学 Q4 CHEMISTRY, MULTIDISCIPLINARY Doklady Chemistry Pub Date : 2024-01-20 DOI:10.1134/s0012500823600967

M. M. Seitkalieva, A. V. Vavina, E. N. Strukova

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引用次数: 0

摘要

摘要利用广泛存在的硬脂生产脂肪酸衍生离子液体（ILs）的可能性已首次得到证实。以咪唑鎓、吡啶鎓和含有长链烷基取代基的季铵阳离子为基础，制备了新型两亲性离子液体。合成的化合物具有与已知抗菌化合物相当的生物活性。与二取代衍生物相比，带有一个烷基取代基的 IL 具有更高的细胞毒性和抗菌活性。

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Stearin as a Starting Material for the Synthesis of Biologically Active Ionic Liquids

Abstract

The possibility of using widely available stearin to produce fatty acid-derived ionic liquids (ILs) has been shown for the first time. New amphiphilic ILs based on imidazolium, pyridinium, and quaternary ammonium cations containing long-chain alkyl substituents have been prepared. The synthesized compounds have been shown to have biological activity comparable to known antimicrobial compounds. ILs with one alkyl substituent have higher cytotoxicity and antimicrobial activity compared to disubstituted derivatives.

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来源期刊

Doklady Chemistry 化学-化学综合

CiteScore

1.20

自引率

12.50%

发文量

审稿时长

6-12 weeks

期刊介绍： Doklady Chemistry is a journal that publishes new research in chemistry and chemical engineering of great significance. Initially the journal was a forum of the Russian Academy of Science and published only best contributions from Russia in the form of short articles. Now the journal welcomes submissions from any country in the English or Russian language. Every manuscript must be recommended by Russian or foreign members of the Russian Academy of Sciences.