治疗细菌性呼吸道感染的脂基纳米药物:现状与新前景。

Nanomedicine (London, England) Pub Date : 2024-02-01 Epub Date: 2024-01-25 DOI:10.2217/nnm-2023-0243
Eva María Arroyo-Urea, María Lázaro-Díez, Junkal Garmendia, Fernando Herranz, Ana González-Paredes
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引用次数: 0

摘要

抗菌药耐药性对全球构成的威胁要求我们采取紧急行动,开发有效的药物。下呼吸道感染仍然是全球最致命的传染病,由于细菌形成顽固的生物膜,治疗起来往往具有挑战性。与传统抗生素相比,新型抗感染药物的耐药性更低,这一点已达成共识,从而引发了对创新抗菌剂的广泛研究。这篇综述探讨了为应对细菌呼吸道感染(尤其是涉及生物膜生长的感染)而开发的脂基纳米药物的最新进展;重点关注改进药物的生物利用度和靶向性,并着重介绍了提高治疗效果的新策略,同时强调了在这一充满活力的领域继续开展研究的重要性。
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Lipid-based nanomedicines for the treatment of bacterial respiratory infections: current state and new perspectives.

The global threat posed by antimicrobial resistance demands urgent action and the development of effective drugs. Lower respiratory tract infections remain the deadliest communicable disease worldwide, often challenging to treat due to the presence of bacteria that form recalcitrant biofilms. There is consensus that novel anti-infectives with reduced resistance compared with conventional antibiotics are needed, leading to extensive research on innovative antibacterial agents. This review explores the recent progress in lipid-based nanomedicines developed to counteract bacterial respiratory infections, especially those involving biofilm growth; focuses on improved drug bioavailability and targeting and highlights novel strategies to enhance treatment efficacy while emphasizing the importance of continued research in this dynamic field.

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