前列腺癌患者腹部计算机断层扫描检测到的治疗前肺间质异常。

IF 1 4区 医学 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Journal of Computer Assisted Tomography Pub Date : 2024-05-01 Epub Date: 2024-01-25 DOI:10.1097/RCT.0000000000001571
Hyun Jin Kim, Won Gi Jeong, Jeong Yeop Lee, Hyo-Jae Lee, Byung Chan Lee, Hyo Soon Lim, Yun-Hyeon Kim
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引用次数: 0

摘要

目的:前列腺癌和肺间质异常(ILA)具有相似的风险因素,即男性和高龄。本研究旨在调查首次到泌尿科就诊并在一年内接受腹部计算机断层扫描(CT)的前列腺癌患者在治疗前出现肺间质异常(ILA)的比例。此外,我们还旨在评估前列腺癌患者治疗前 ILA 与长期生存之间的关系:这项研究的对象是 2005 年至 2016 年期间首次到泌尿科就诊的前列腺癌患者,他们在 1 年内接受了腹部 CT 检查。胸部放射科医生通过检查腹部 CT 扫描到的肺底,评估是否存在 ILA。采用卡普兰-梅耶分析和对数秩检验评估治疗前ILA与生存率之间的关系。根据ILA的存在情况,采用z检验评估12个月、36个月和60个月的具体生存率。Cox回归分析用于评估死亡率的风险因素:共纳入 173 名患者(平均年龄为 70.23 ± 7.98 岁)。10.4%的患者在治疗前出现ILA。患有 ILA 的患者更有可能是老年人和吸烟者。治疗前ILA与生存率低有关(P < 0.001)。年龄≥70岁(危险比[HR],1.98;95% 置信区间[CI],1.24-3.16;P = 0.004)、转移期(HR,2.26;95% CI,1.36-3.74;P = 0.002)和ILA(HR,1.96;95% CI,1.06-3.60;P = 0.031)是死亡率的独立危险因素。ILA(HR,3.94;95% CI,1.78-8.72;P = 0.001)是局部分期前列腺癌患者死亡的唯一独立风险因素:本研究为前列腺癌患者治疗前ILA的影响提供了重要见解。在腹部 CT 扫描中,前列腺癌患者的肺部基底中观察到大量治疗前 ILA。此外,治疗前 ILA 是导致死亡的危险因素。因此,应在前列腺癌患者的腹部 CT 扫描中对肺部基底进行常规检查。这一结果可能有助于临床医生为前列腺癌患者制定个性化的治疗策略。
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Pretreatment Interstitial Lung Abnormalities Detected on Abdominal Computed Tomography Scans in Prostate Cancer Patients.

Objective: Prostate cancer and interstitial lung abnormality (ILA) share similar risk factor, which is men and older age. The purpose of this study was to investigate the prevalence of pretreatment ILA among prostate cancer patients who underwent abdominal computed tomography (CT) within 1 year at their first visit to the urology department. In addition, we aimed to assess the association between pretreatment ILA and long-term survival in prostate cancer patients.

Methods: This study was conducted in patients who had a first visit for prostate cancer at urology department between 2005 and 2016 and underwent an abdominal CT within 1 year. A thoracic radiologist evaluated the presence of ILA through inspecting the lung base scanned on an abdominal CT. The association between pretreatment ILA and survival was assessed using Kaplan-Meier analysis with log-rank test. Specific survival rates at 12, 36, and 60 months according to the presence of ILA were evaluated using z -test. Cox regression analysis was used to assess the risk factors of mortality.

Results: A total of 173 patients were included (mean age, 70.23 ± 7.98 years). Pretreatment ILA was observed in 10.4% of patients. Patients with ILA were more likely to be older and current smokers. Pretreatment ILA was associated with poor survival ( P < 0.001). Age ≥70 years (hazards ratio [HR], 1.98; 95% confidence interval [CI], 1.24-3.16; P = 0.004), metastatic stage (HR, 2.26; 95% CI, 1.36-3.74; P = 0.002), and ILA (HR, 1.96; 95% CI, 1.06-3.60; P = 0.031) were the independent risk factors of mortality. An ILA (HR, 3.94; 95% CI, 1.78-8.72; P = 0.001) was the only independent risk factor of mortality in localized stage prostate cancer patients.

Conclusions: This study provides important insights into the unexplored effect of pretreatment ILA in prostate cancer patients. Pretreatment ILAs were observed considerably in the lung bases scanned on the abdominal CT scans among prostate cancer patients. Furthermore, pretreatment ILAs were the risk factor of mortality. Therefore, lung bases should be routinely inspected in the abdominal CT scans of prostate cancer patients. This result may help clinicians in establishing personalized management strategy of prostate cancer patients.

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来源期刊
CiteScore
2.50
自引率
0.00%
发文量
230
审稿时长
4-8 weeks
期刊介绍: The mission of Journal of Computer Assisted Tomography is to showcase the latest clinical and research developments in CT, MR, and closely related diagnostic techniques. We encourage submission of both original research and review articles that have immediate or promissory clinical applications. Topics of special interest include: 1) functional MR and CT of the brain and body; 2) advanced/innovative MRI techniques (diffusion, perfusion, rapid scanning); and 3) advanced/innovative CT techniques (perfusion, multi-energy, dose-reduction, and processing).
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