循环肿瘤细胞在实体瘤患者中的临床应用。

IF 4.2 3区 医学 Q2 ONCOLOGY Clinical & Experimental Metastasis Pub Date : 2024-08-01 Epub Date: 2024-01-28 DOI:10.1007/s10585-024-10267-5
Daniel J Smit, Svenja Schneegans, Klaus Pantel
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引用次数: 0

摘要

液体活检分析的概念早在十多年前就已提出。自这一术语确立以来,已经取得了巨大进步,在基础研究和临床试验中对大量方法和分析物进行了研究。液体活检指的是一种基于体液的活检方法,具有微创性,最重要的是可以通过连续采血对肿瘤反应进行密集监测。血液是液体活检分析中最重要的分析物,为大量细胞、细胞衍生产物、游离核酸、蛋白质和囊泡提供了易于获取的来源。截至目前,PubMed 上已收录了 12,000 多篇包含液体活检一词的论文。在这篇手稿中,我们认真回顾了液体活检目前的意义,特别关注循环肿瘤细胞,并描述了液体活检在临床标准治疗指南中实施前需要解决的障碍。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Clinical applications of circulating tumor cells in patients with solid tumors.

The concept of liquid biopsy analysis has been established more than a decade ago. Since the establishment of the term, tremendous advances have been achieved and plenty of methods as well as analytes have been investigated in basic research as well in clinical trials. Liquid biopsy refers to a body fluid-based biopsy that is minimal-invasive, and most importantly, allows dense monitoring of tumor responses by sequential blood sampling. Blood is the most important analyte for liquid biopsy analyses, providing an easily accessible source for a plethora of cells, cell-derived products, free nucleic acids, proteins as well as vesicles. More than 12,000 publications are listed in PubMed as of today including the term liquid biopsy. In this manuscript, we critically review the current implications of liquid biopsy, with special focus on circulating tumor cells, and describe the hurdles that need to be addressed before liquid biopsy can be implemented in clinical standard of care guidelines.

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来源期刊
CiteScore
7.80
自引率
5.00%
发文量
55
审稿时长
12 months
期刊介绍: The Journal''s scope encompasses all aspects of metastasis research, whether laboratory-based, experimental or clinical and therapeutic. It covers such areas as molecular biology, pharmacology, tumor biology, and clinical cancer treatment (with all its subdivisions of surgery, chemotherapy and radio-therapy as well as pathology and epidemiology) insofar as these disciplines are concerned with the Journal''s core subject of metastasis formation, prevention and treatment.
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