逆行性健忘症与压力引起的消退障碍有关：与时间有关，但并不那么容易被遗忘。

IF 1.8 4区医学 Q4 NEUROSCIENCES Learning & memory Pub Date : 2024-01-29 Print Date: 2024-01-01 DOI:10.1101/lm.053895.123

James F Briggs, Kaitlyn M McMullen

{"title":"逆行性健忘症与压力引起的消退障碍有关：与时间有关，但并不那么容易被遗忘。","authors":"James F Briggs, Kaitlyn M McMullen","doi":"10.1101/lm.053895.123","DOIUrl":null,"url":null,"abstract":"We investigated whether retrograde amnesia for the stress-induced impairment of extinction retrieval shares similar characteristics with original acquisition memories. The first experiment demonstrated that cycloheximide administered shortly after a single restraint stress session alleviated the impairment of extinction retrieval but not when administered following a longer delay (i.e., the amnesia for stress is time-dependent). A second experiment showed that the retrograde amnesia for stress could be alleviated by a second brief exposure to the stressor. These results demonstrating that amnesia for stress shares characteristics similar to original memories are explained using a retrieval-based memory integration model of retrograde amnesia.","PeriodicalId":18003,"journal":{"name":"Learning & memory","volume":"31 1-2","pages":""},"PeriodicalIF":1.8000,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10903941/pdf/","citationCount":"0","resultStr":"{\"title\":\"Retrograde amnesia for the stress-induced impairment of extinction: time-dependent and not so forgotten.\",\"authors\":\"James F Briggs, Kaitlyn M McMullen\",\"doi\":\"10.1101/lm.053895.123\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"We investigated whether retrograde amnesia for the stress-induced impairment of extinction retrieval shares similar characteristics with original acquisition memories. The first experiment demonstrated that cycloheximide administered shortly after a single restraint stress session alleviated the impairment of extinction retrieval but not when administered following a longer delay (i.e., the amnesia for stress is time-dependent). A second experiment showed that the retrograde amnesia for stress could be alleviated by a second brief exposure to the stressor. These results demonstrating that amnesia for stress shares characteristics similar to original memories are explained using a retrieval-based memory integration model of retrograde amnesia.\",\"PeriodicalId\":18003,\"journal\":{\"name\":\"Learning & memory\",\"volume\":\"31 1-2\",\"pages\":\"\"},\"PeriodicalIF\":1.8000,\"publicationDate\":\"2024-01-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10903941/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Learning & memory\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1101/lm.053895.123\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/1/1 0:00:00\",\"PubModel\":\"Print\",\"JCR\":\"Q4\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Learning & memory","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1101/lm.053895.123","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"Print","JCR":"Q4","JCRName":"NEUROSCIENCES","Score":null,"Total":0}

引用次数: 0

摘要

我们研究了逆行性遗忘是否与原始获得记忆具有相似的特征。第一个实验表明，在单次束缚应激后不久给予环己亚胺可减轻消退检索的障碍，但在延迟较长时间后给予环己亚胺则不会缓解（即应激遗忘与时间有关）。第二个实验表明，第二次短暂接触应激源可减轻对应激的逆行性遗忘。这些结果表明，应激性遗忘症与原始记忆具有相似的特征，这可以用逆行性遗忘症的检索记忆整合模型来解释。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

Retrograde amnesia for the stress-induced impairment of extinction: time-dependent and not so forgotten.

We investigated whether retrograde amnesia for the stress-induced impairment of extinction retrieval shares similar characteristics with original acquisition memories. The first experiment demonstrated that cycloheximide administered shortly after a single restraint stress session alleviated the impairment of extinction retrieval but not when administered following a longer delay (i.e., the amnesia for stress is time-dependent). A second experiment showed that the retrograde amnesia for stress could be alleviated by a second brief exposure to the stressor. These results demonstrating that amnesia for stress shares characteristics similar to original memories are explained using a retrieval-based memory integration model of retrograde amnesia.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Learning & memory 医学-神经科学

CiteScore

3.60

自引率

5.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The neurobiology of learning and memory is entering a new interdisciplinary era. Advances in neuropsychology have identified regions of brain tissue that are critical for certain types of function. Electrophysiological techniques have revealed behavioral correlates of neuronal activity. Studies of synaptic plasticity suggest that some mechanisms of memory formation may resemble those of neural development. And molecular approaches have identified genes with patterns of expression that influence behavior. It is clear that future progress depends on interdisciplinary investigations. The current literature of learning and memory is large but fragmented. Until now, there has been no single journal devoted to this area of study and no dominant journal that demands attention by serious workers in the area, regardless of specialty. Learning & Memory provides a forum for these investigations in the form of research papers and review articles.