深入了解合成具有多种治疗活性的喹啉杂化物的各种方法

IF 0.7 4区 化学 Q4 CHEMISTRY, ORGANIC Letters in Organic Chemistry Pub Date : 2024-01-26 DOI:10.2174/0115701786279549231228125141
Ruchi Sharma, Chandana Majee, Rupa Mazumder, Avijit Mazumder, Swarupanjali Padhi, Akshay Kumar
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引用次数: 0

摘要

:喹啉是一种具有广阔前景和突出生物活性的 N 基杂环化合物。本综述论文旨在讨论喹啉衍生物的合成方法,这些方法是从各种研究文章中总结出来的,用于制备具有不同治疗活性的喹啉衍生物,如抗真菌活性、抗癌活性、抗惊厥活性、抗结核活性、抗疟活性、抗老年痴呆活性等。这项综合研究符合所有证明喹啉衍生物的合成和生物学方面的相关出版物和商标出版物。研究人员合成了各种类型的喹啉杂化物,并对其治疗活性进行了分析,包括抗癌、抗结核、抗老年痴呆、抗氧化和抗真菌活性。喹啉是一种平面杂芳香族化合物,化学式为 C9H7N。几种著名的喹啉骨架合成路线包括弗里德兰德合成法、克诺尔喹啉合成法和斯克劳普反应。研究人员可根据所研究的确切结构和治疗作用,使用其他技术或改变现有策略来达到目的。起始材料的可用性、反应条件、可扩展性、所需的区域选择性以及喹啉核心的官能化等因素都会影响合成方法的选择。本综述涵盖了有关多种喹啉及其衍生物的合成程序及其生物学和药理学应用的最新文献和知识。
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Insight into the Various Approaches Undertaken for the Synthesis of Quinoline Hybrids Imparting Diverse Therapeutic Activities
: Quinoline is one of the promising and prominent biologically active N-based heterocyclic compounds. This review paper aims to discuss the synthetic approaches, summarized from various research articles on the preparation of quinoline derivatives intended for different therapeutic activities like antifungal activity, anticancer activity, anticonvulsant activity, antitubercular activity, antimalarial activity, anti-Alzheimer activity and so on. The comprehensive study complies with all related publications and trademark publications demonstrating the synthesis and biological aspects of quinoline derivatives. Various types of quinoline hybrids were synthesized and treated for therapeutic activity, including anticancer, antitubercular, anti-Alzheimer, antioxidant, and antifungal activity, which have been analyzed. Quinoline is a planner hetero-aromatic compound with the chemical formula C9H7N. Several wellknown synthetic routes to the quinoline skeleton include Friedlander synthesis, Knorr quinoline synthesis, and Skraup reaction. Researchers may use other techniques or alter current strategies to reach their objectives, depending on what exact structure and therapeutic action they are investigating. The availability of starting materials, reaction conditions, scalability, desired regioselectivity, and functionalization of the quinoline core all have a role in the choice of synthetic method. This review covers the latest literature and knowledge on the synthetic procedures for numerous quinoline and its derivatives and their biological and pharmacological application.
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来源期刊
Letters in Organic Chemistry
Letters in Organic Chemistry 化学-有机化学
CiteScore
1.30
自引率
12.50%
发文量
135
审稿时长
7 months
期刊介绍: Aims & Scope Letters in Organic Chemistry publishes original letters (short articles), research articles, mini-reviews and thematic issues based on mini-reviews and short articles, in all areas of organic chemistry including synthesis, bioorganic, medicinal, natural products, organometallic, supramolecular, molecular recognition and physical organic chemistry. The emphasis is to publish quality papers rapidly by taking full advantage of latest technology for both submission and review of the manuscripts. The journal is an essential reading for all organic chemists belonging to both academia and industry.
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