基于 8-氮杂螺[5.6]十二-10-烯支架的取代吡咯衍生物的合成

Molbank Pub Date : 2024-01-25 DOI:10.3390/m1765

Ildar R. Iusupov, V. Tafeenko, A. Altieri, A. Kurkin

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摘要

这项研究描述了基于 8-氮杂螺[5.6]十二-10-烯的螺环化合物的合成。利用偶联反应从螺环 1,2,3- 三唑制备了非对映纯的吡咯衍生物。通过 1H 和 13C NMR 光谱及 HRMS 对所制备的化合物进行了表征，并通过 X 射线衍射对其中一种化合物的晶体学特征进行了研究。

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Synthesis of Substituted Pyrrole Derivatives Based on 8-Azaspiro[5.6]dodec-10-ene Scaffold

This work describes the synthesis of spirocyclic compounds based on 8-azaspiro[5.6]dodec-10-ene. Diastereomerically pure pyrrole derivatives were prepared from the spirocyclic 1,2,3-triazole using a coupling reaction. The resulting compounds were characterized via 1H and 13C NMR spectroscopy and HRMS, and the crystallographic characteristics of one of them were studied via X-ray diffraction.

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