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引用次数: 0
摘要
摘要艾滋病病毒感染者(PWH)罹患心血管疾病(CVDs)的风险较高,包括心肌梗死、心力衰竭、心脏性猝死以及其他心血管疾病表现。导致持续炎症的慢性免疫失调在艾滋病病毒感染者中很常见,尤其是那些病毒血症持续存在且 CD4+ T 细胞恢复受损的艾滋病病毒感染者。这种炎症环境与常见的合并症(如血脂异常和吸烟)以及在较小程度上与抗逆转录病毒疗法的脱靶效应一起,是导致 PWH 患者心血管疾病的主要因素。在这篇综述中,我们将讨论有关增加 PWH 心血管疾病风险的临床和机理证据、对特定心血管疾病表现的影响以及在数据不断变化的情况下进行管理的实用指南。
Evolving mechanisms and presentations of cardiovascular disease in people with HIV: implications for management.
People with HIV (PWH) are at elevated risk for cardiovascular diseases (CVDs), including myocardial infarction, heart failure, and sudden cardiac death, among other CVD manifestations. Chronic immune dysregulation resulting in persistent inflammation is common among PWH, particularly those with sustained viremia and impaired CD4+ T cell recovery. This inflammatory milieu is a major contributor to CVDs among PWH, in concert with common comorbidities (such as dyslipidemia and smoking) and, to a lesser extent, off-target effects of antiretroviral therapy. In this review, we discuss the clinical and mechanistic evidence surrounding heightened CVD risks among PWH, implications for specific CVD manifestations, and practical guidance for management in the setting of evolving data.
期刊介绍:
Clinical Microbiology Reviews (CMR) is a journal that primarily focuses on clinical microbiology and immunology.It aims to provide readers with up-to-date information on the latest developments in these fields.CMR also presents the current state of knowledge in clinical microbiology and immunology.Additionally, the journal offers balanced and thought-provoking perspectives on controversial issues in these areas.