TREM2 在胶质母细胞瘤中介导吞噬作用

IF 28.2 1区 医学 Q1 CLINICAL NEUROLOGY Nature Reviews Neurology Pub Date : 2024-02-07 DOI:10.1038/s41582-024-00935-1
Lisa Kiani
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引用次数: 0

摘要

一项新的研究表明,在小鼠和人类胶质瘤中,髓系细胞上表达的触发受体2(TREM2)是一种重要的吞噬免疫调节剂。研究发现,TREM2通过脾脏酪氨酸激酶途径调节吞噬作用,与其他癌症不同的是,TREM2的表达与免疫抑制途径无关。与TREM2-细胞相比,TREM2+髓系细胞显示出更高的肿瘤摄取率,这表明TREM2-增强策略可能是胶质瘤的一种治疗方法。
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TREM2 mediates phagocytosis in glioblastoma
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来源期刊
Nature Reviews Neurology
Nature Reviews Neurology 医学-临床神经学
CiteScore
29.90
自引率
0.80%
发文量
138
审稿时长
6-12 weeks
期刊介绍: Nature Reviews Neurology aims to be the premier source of reviews and commentaries for the scientific and clinical communities we serve. We want to provide an unparalleled service to authors, referees, and readers, and we work hard to maximize the usefulness and impact of each article. The journal publishes Research Highlights, Comments, News & Views, Reviews, Consensus Statements, and Perspectives relevant to researchers and clinicians working in the field of neurology. Our broad scope ensures that the work we publish reaches the widest possible audience. Our articles are authoritative, accessible, and enhanced with clearly understandable figures, tables, and other display items. This page gives more detail about the aims and scope of the journal.
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