神经类固醇可减轻大鼠癫痫发作

IF 28.2 1区 医学 Q1 CLINICAL NEUROLOGY Nature Reviews Neurology Pub Date : 2024-02-07 DOI:10.1038/s41582-024-00933-3
Lisa Kiani
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引用次数: 0

摘要

事实证明,使用3β-羟基类固醇脱氢酶抑制剂曲洛司坦治疗凯尼克酸大鼠颞叶癫痫模型可减少自发性癫痫发作的次数。对治疗后新皮质和海马中神经类固醇水平的测量显示,异孕酮、孕烯醇酮和孕酮等各种神经类固醇的水平都有大幅提高。这些研究结果补充了之前的研究,表明某些神经类固醇具有抗惊厥特性。
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Neurosteroids alleviate seizures in rats
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来源期刊
Nature Reviews Neurology
Nature Reviews Neurology 医学-临床神经学
CiteScore
29.90
自引率
0.80%
发文量
138
审稿时长
6-12 weeks
期刊介绍: Nature Reviews Neurology aims to be the premier source of reviews and commentaries for the scientific and clinical communities we serve. We want to provide an unparalleled service to authors, referees, and readers, and we work hard to maximize the usefulness and impact of each article. The journal publishes Research Highlights, Comments, News & Views, Reviews, Consensus Statements, and Perspectives relevant to researchers and clinicians working in the field of neurology. Our broad scope ensures that the work we publish reaches the widest possible audience. Our articles are authoritative, accessible, and enhanced with clearly understandable figures, tables, and other display items. This page gives more detail about the aims and scope of the journal.
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